Vasmehjani Abbas Ahmadi, Yaghubi Sajad, Erfani Yousef, Hajikhezri Zamaneh, Farahmand Mohammad, Shayestehpour Mohammad, Adeli Omid Ali, Beiranvand Maryam
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Department of Clinical Microbiology, Iranshahr University of Medical Sciences, Iranshahr, Iran.
Int J Prev Med. 2020 Nov 26;11:178. doi: 10.4103/ijpvm.IJPVM_260_18. eCollection 2020.
Hepatitis B virus is one of the transfusion transmissible infections. Despite the availability of hepatitis B virus (HBV) vaccine and screening tests but still danger of virus transmission via blood transfusion is high in some regions. The objective of this study was to determine the trend of seroprevalence of hepatitis B in over an 11-year period (2005-2015).
In this study, 355,083 blood donors were estimated for hepatitis B surface antigen (HBs Ag) seropositivity during 2005-2015 who referred to blood infusion centers of Lorestan province. Third-generation ELISA method was used to detect HBs Ag.
The prevalence of HBs Ag in blood donors was 0.29% (1017). It was decreased steadily from 2005 to 2015 (0.68% to 0.12%) but increased in 2008 year. The trend prevalence of HBs Ag seropositivity significantly decreased over the study period ( < 0.001). The decline in HBV infection rates was more prominent in regular and repeated donor's groups compared to people who donated blood for the first time ( < 0.001).
The result of present study was indicated, Lorestan city in west of Iran can be classified as a low-income region because the low prevalence of HBs Ag in blood donors. Also the prevalence of HBs Ag in first-time donors was higher than other groups.
乙型肝炎病毒是可通过输血传播的感染源之一。尽管有乙肝病毒（HBV）疫苗和筛查检测手段，但在某些地区，通过输血传播病毒的风险仍然很高。本研究的目的是确定11年期间（2005 - 2015年）乙肝血清流行率的变化趋势。
在本研究中，对2005 - 2015年期间前往洛雷斯坦省输血中心的355,083名献血者进行了乙肝表面抗原（HBs Ag）血清阳性检测。采用第三代酶联免疫吸附测定法检测HBs Ag。
献血者中HBs Ag的流行率为0.29%（1017例）。从2005年到2015年呈稳步下降趋势（从0.68%降至0.12%），但在2008年有所上升。在研究期间，HBs Ag血清阳性的流行趋势显著下降（<0.001）。与首次献血者相比，定期和重复献血者组中HBV感染率的下降更为明显（<0.001）。
本研究结果表明，伊朗西部的洛雷斯坦市可被归类为低收入地区，因为献血者中HBs Ag的流行率较低。此外，首次献血者中HBs Ag的流行率高于其他组。
