伊朗亚兹德地区乙肝表面抗原阴性、乙肝核心抗体阳性献血者中乙肝病毒DNA的频率
Frequency of hepatitis B virus-DNA among hepatitis B surface-Ag negative, anti-hepatitis B core antibody-positive blood donors in Yazd, Iran.
作者信息
Vaziri Mahtab, Shahshahani Hayedeh Javadzadeh
机构信息
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Yazd, Iran.
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
出版信息
Asian J Transfus Sci. 2021 Jul-Dec;15(2):179-182. doi: 10.4103/ajts.AJTS_155_18. Epub 2021 Nov 1.
BACKGROUND
The diagnosis of hepatitis B infection in most blood transfusion centers is based on hepatitis B surface (HBs) antigen detection by an enzyme immunoassay method. This study aimed to determine the frequency of hepatitis B core (HBc) antibody, HBs antibody, and hepatitis B virus (HBV) DNA among HBs antigen-negative healthy blood donors of Yazd province, Iran.
MATERIALS AND METHODS
This cross-sectional study was conducted on 1500 healthy blood donor samples negative for HBs antigen, hepatitis C virus antibody, human immunodeficiency virus antigen/antibody, and rapid plasma regain tests. All samples were screened for HBc antibody test. HBs antibody and real-time polymerase chain reaction were performed for HBc antibody-positive samples.
RESULTS
HBc antibody was positive in 74 (4.9%) samples and 11 (14.9%) of 74 positive samples for HBc antibody were negative for HBs antibody. Sixty-three (85.1%) positive samples for HBc antibody had HBs antibody titer over 10 IU/L, and 43 (58.1%) had HBs antibody titer over 100 IU/L. There was no hepatitis B DNA-positive sample in the present study.
CONCLUSIONS
The study results suggest that there is a very low risk for transmission of HBV through blood donors of Yazd, Iran.
背景
大多数输血中心通过酶免疫测定法检测乙型肝炎表面（HBs）抗原以诊断乙型肝炎感染。本研究旨在确定伊朗亚兹德省HBs抗原阴性的健康献血者中乙型肝炎核心（HBc）抗体、HBs抗体和乙型肝炎病毒（HBV）DNA的频率。
材料与方法
本横断面研究对1500份HBs抗原、丙型肝炎病毒抗体、人类免疫缺陷病毒抗原/抗体及快速血浆反应素试验均为阴性的健康献血者样本进行检测。所有样本均进行HBc抗体检测。对HBc抗体阳性样本进行HBs抗体及实时聚合酶链反应检测。
结果
74份（4.9%）样本HBc抗体呈阳性，74份HBc抗体阳性样本中有11份（14.9%）HBs抗体呈阴性。63份（85.1%）HBc抗体阳性样本的HBs抗体滴度超过10 IU/L，43份（58.1%）的HBs抗体滴度超过100 IU/L。本研究中未发现HBV DNA阳性样本。
结论
研究结果表明，通过伊朗亚兹德的献血者传播HBV的风险非常低。
Zotero 插件