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急性淋巴细胞白血病中导致发热性中性粒细胞减少的真菌血症的罕见病因

: A Rare Cause of Fungemia Causing Febrile Neutropenia in Acute Lymphoblastic Leukemia.

作者信息

Mehta Vibha, Mohanty Aroop, Meena Suneeta, Rahul J S, Uttam Kumar Nath, Chattopadhyay Debranjani, Bakliwal Anamika, Choudhary Ranjana, Gupta Pratima

机构信息

PDCC Hepatic and Transplant Virology, ILBS, New Delhi, India.

Department of Clinical Microbiology, AIIMS, Gorakhpur, India.

出版信息

Case Rep Infect Dis. 2020 Dec 29;2020:8847853. doi: 10.1155/2020/8847853. eCollection 2020.

Abstract

bloodstream infection is the major cause of increased morbidity and mortality (20-49%) in hospitalized patients in both paediatric and adult age groups. Due to the increase in the number of immunocompromised patients, other important species such as and are emerging. One such organism, , previously known as (teleomorph stages of several species), is increasingly being reported as a cause of fungemia in neonatal intensive care units and is now increasingly being reported in a lot of immunosuppressive conditions such as interstitial lung disease, endocarditis, enteritis, corticosteroids, and chemotherapy uptake. Though this yeast is ubiquitous in nature, systemic infections from isolated cases and sporadic outbreaks with high mortality have been reported in ICUs, which emphasize the importance to consider this fungus within the diagnostic possibilities. Here, we report a case of catheter-related bloodstream infection (CRBSI) caused by in a leukemic immunosuppressed patient who was successfully treated by early detection and treatment of this emerging fungus.

摘要

血流感染是儿科和成人住院患者发病率和死亡率增加(20%-49%)的主要原因。由于免疫功能低下患者数量的增加,其他重要菌种如[具体菌种1]和[具体菌种2]正在出现。其中一种微生物,[菌种名称],以前被称为[曾用名](几种[相关菌种名称]的有性阶段),越来越多地被报道为新生儿重症监护病房真菌血症的病因,现在在许多免疫抑制情况下也越来越多地被报道,如间质性肺病、心内膜炎、肠炎、使用皮质类固醇和化疗。尽管这种酵母在自然界中无处不在,但重症监护病房报告了孤立病例和散发性暴发导致的全身感染,且死亡率很高,这凸显了在诊断可能性中考虑这种真菌的重要性。在此,我们报告一例白血病免疫抑制患者由[菌种名称]引起的导管相关血流感染(CRBSI)病例,该患者通过早期发现和治疗这种新出现的真菌而成功治愈。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185d/7785382/6709530a74e9/CRIID2020-8847853.001.jpg

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