一种针对罕见真菌的新型诊断方法：FcMBL有助于在免疫功能低下的新生儿中进行鉴定。
A novel diagnostic method for a rare fungus: FcMBL facilitates identification in an immunocompromised neonate.
作者信息
Higgins Conor J, Kite Kerry-Anne, Klein Nigel, Super Michael, McCurdy Michael T, Hargrave Darren
机构信息
The Robert Larner, M.D. College of Medicine at the University of Vermont, Burlington, VT, USA.
Great Ormond Street Institute of Child Health, London, United Kingdom.
出版信息
Med Mycol Case Rep. 2023 Oct 21;42:100614. doi: 10.1016/j.mmcr.2023.100614. eCollection 2023 Dec.
Fungemia negatively impacts patient outcomes, current diagnostics lack sensitivity to identify emerging rare mycoses, and fungal infections are increasing in prevalence, variety, and resistance. We report a case of in an immunocompromised neonate in which FcMBL bead-based matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) resulted in species identification roughly 30 hours before standard pathogen identification methods. Deploying FcMBL bead-based MALDI-TOF MS may improve the speed and accuracy of identification, and therefore treatment, of rare pathogens.
真菌血症对患者预后产生负面影响，当前的诊断方法缺乏识别新出现的罕见真菌病的敏感性，并且真菌感染在患病率、种类和耐药性方面都在增加。我们报告了一例免疫功能低下新生儿的病例，其中基于FcMBL磁珠的基质辅助激光解吸/电离飞行时间（MALDI-TOF）质谱（MS）比标准病原体鉴定方法提前约30小时鉴定出菌种。采用基于FcMBL磁珠的MALDI-TOF MS可能会提高罕见病原体鉴定的速度和准确性，从而改善治疗效果。
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