Rashid Romana R, Fazal Ayesha, Khan Qudsia U, Ul Qamar Misbah, Ahmed Farooq, Laique Talha
Physiology, Akhtar Saeed Medical and Dental College, Lahore, PAK.
Physiology, Combined Military Hospital (CMH) Lahore Medical and Dental College, Lahore, PAK.
Cureus. 2020 Dec 11;12(12):e12028. doi: 10.7759/cureus.12028.
Introduction Diabetes mellitus (DM) is a disease of carbohydrate, protein, and fats metabolism that results in hyperglycemia. It may also result from defects in the secretion of insulin from beta cells or in its action on target cells or both. Objective To determine the levels of brain-derived neurotrophic factor (BDNF) and glycated hemoglobulin (HbA1c) with the progression of retinopathy. Methodology The study was done on 80 patients who were divided into four groups (A, B, C, D), with 20 individuals each, on the basis of their diabetic status and fundoscopic findings. Serum BDNF levels were measured by using an enzyme-linked immunosorbent assay kit (Glory Science Co., Taichung City, Taiwan). Results On analysis, a significant decline was seen in serum BDNF levels in diabetics as compared with non-diabetics (p < 0.001), but a significant reduction in levels with the progression of retinopathy was observed (p < 0.001). Statistical analysis All the data were processed using the Statistical Package for the Social Sciences (SPSS) v20.0 (IBM Corp., Armonk, NY). Conclusion There is a significant decline in serum BDNF levels in type 2 diabetics with retinopathy in comparison with the healthy control group.
引言 糖尿病（DM）是一种碳水化合物、蛋白质和脂肪代谢疾病，会导致血糖升高。它也可能由β细胞胰岛素分泌缺陷、胰岛素对靶细胞的作用缺陷或两者兼而有之引起。目的 确定随着视网膜病变进展脑源性神经营养因子（BDNF）和糖化血红蛋白（HbA1c）的水平。方法 该研究对80名患者进行，根据他们的糖尿病状况和眼底镜检查结果将其分为四组（A、B、C、D），每组20人。使用酶联免疫吸附测定试剂盒（台湾台中市荣耀科学公司）测量血清BDNF水平。结果 分析发现，与非糖尿病患者相比，糖尿病患者血清BDNF水平显著下降（p < 0.001），但随着视网膜病变进展，水平显著降低（p < 0.001）。统计分析 所有数据均使用社会科学统计软件包（SPSS）v20.0（IBM公司，纽约州阿蒙克）进行处理。结论 与健康对照组相比，患有视网膜病变的2型糖尿病患者血清BDNF水平显著下降。
