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生殖细胞肿瘤的腹膜后淋巴结清扫术

Retroperitoneal lymph node dissection for germ cell tumour.

作者信息

Tran Vy, Gibson Luke, Sengupta Shomik

机构信息

Department of Urology, Eastern Health, Box Hill, Victoria, Australia.

Eastern health Clinical School, Monash University, Box Hill, Victoria, Australia.

出版信息

Transl Androl Urol. 2020 Dec;9(6):3103-3111. doi: 10.21037/tau-2019-suc-18.

DOI:10.21037/tau-2019-suc-18
PMID:33457283
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7807376/
Abstract

Retroperitoneal lymph node dissection (RPLND) is an infrequently used, but important part of the management of men with metastatic germ cell tumours. The surgery aims to remove the lymph nodes from the primary retroperitoneal landing site from testicular tumours, usually accomplished by removing tissue surrounding the great vessels using a split-and-roll technique. RPLND may be carried out as a primary surgical procedure for staging or treatment of metastases. More frequently it is undertaken as a follow-up after chemotherapy for a residual mass that may contain viable tumour or teratoma. RPLND is recognised as a major surgery with significant risks of morbidity and complications, particularly loss of ejaculation secondary to damage to hypogastric nerves. In select cases, especially during primary RPLND, nerve-sparing surgery may help preserve ejaculation, which maybe of importance to the young men usually treated for germ cell tumours. In recent years, the development of minimally invasive approaches have also offered a means for potential improvement in the pain and post-operative recovery from RPLND. We conducted a narrative review of the literature to assess indications for RPLND, along with operative approaches and techniques and related outcomes. The majority of available literature is in the form of relatively small retrospective case series, hence additional research in this area is desirable.

摘要

腹膜后淋巴结清扫术(RPLND)是一种不常用但对转移性生殖细胞肿瘤男性患者治疗很重要的方法。该手术旨在切除睾丸肿瘤在腹膜后最初转移部位的淋巴结,通常通过采用劈开翻转技术切除大血管周围的组织来完成。RPLND可作为分期或治疗转移灶的主要外科手术。更常见的是在化疗后对可能含有存活肿瘤或畸胎瘤的残留肿块进行的后续手术。RPLND被认为是一项大手术,存在显著的发病风险和并发症,尤其是因下腹神经损伤导致的射精功能丧失。在某些情况下,特别是在初次RPLND期间,保留神经的手术可能有助于保留射精功能,这对通常接受生殖细胞肿瘤治疗的年轻男性可能很重要。近年来,微创方法的发展也为潜在改善RPLND后的疼痛和术后恢复提供了一种手段。我们对文献进行了叙述性综述,以评估RPLND的适应证、手术方法和技术以及相关结果。现有文献大多是相对较小的回顾性病例系列,因此该领域需要更多研究。

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Eur Urol Oncol. 2021 Aug;4(4):651-658. doi: 10.1016/j.euo.2019.01.014. Epub 2019 Mar 29.
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Robot-assisted retroperitoneal lymph node dissection: Feasibility and outcome in postchemotherapy residual mass in testicular cancer.机器人辅助腹膜后淋巴结清扫术:睾丸癌化疗后残留肿块的可行性及结果
Indian J Urol. 2017 Oct-Dec;33(4):304-309. doi: 10.4103/iju.IJU_8_17.
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Laparoscopic Retroperitoneal Lymph Node Dissection for Clinical Stage I Nonseminomatous Germ Cell Tumors of the Testis: Safety and Efficacy Analyses at a High Volume Center.腹腔镜腹膜后淋巴结清扫术治疗临床Ⅰ期睾丸非精原细胞瘤生殖细胞肿瘤:大容量中心的安全性和疗效分析。
J Urol. 2018 Mar;199(3):741-747. doi: 10.1016/j.juro.2017.09.088. Epub 2017 Sep 28.
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Modified retroperitoneal lymph node dissection for post-chemotherapy residual tumour: a long-term update.化疗后残留肿瘤的改良腹膜后淋巴结清扫术:长期随访更新
BJU Int. 2017 Jul;120(1):104-108. doi: 10.1111/bju.13844. Epub 2017 Apr 11.
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