梅尼埃病的药理、手术及诊断创新：综述
Pharmacological, Surgical and Diagnostic Innovations in Meniere's Disease: A Review.
作者信息
Scarpa A, Ralli M, De Bonis E, Troisi D, Montanino A, Viola P, Chiarella G, Gioacchini F M, Cavaliere M, Cassandro E, Cassandro C
机构信息
Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
Department of Sense Organs, Sapienza University Rome, Rome, Italy; Center for Hearing and Deafness, University at Buffalo, Buffalo, NY 14214, USA.
出版信息
Transl Med UniSa. 2020 Oct 31;23:48-52. doi: 10.37825/2239-9747.1009. eCollection 2020 Oct.
PURPOSE
To investigate literature about pharmacological, surgical, and diagnostic innovations for Meniere's Disease (MD).
SUMMARY
Meniere's disease is an inner ear disorder characterized by the presence of endolymphatic hydrops in the inner ear and symptomatology of recurrent and debilitating vertigo attacks, tinnitus, aural fullness, and fluctuating sensorineural hearing loss. Although many therapeutic options for MD have been proposed during years, no consensus has been reached by the scientific community. In the last decade, many therapeutic options have been proposed, as intratympanic steroid, intratympanic gentamicin, and intravenous glycerol. Recently, the role of the antisecretory factor in the diet of MD patients have been investigated. Surgery is recommended for intractable MD; some authors proposed new approaches including transcanal endoscopic infracochlear vestibular neurectomy, new marsupiliazation technique in sac surgery, and tenotomy of the stapedius and tensor tympani muscles.
目的
调查有关梅尼埃病（MD）的药理学、外科手术及诊断创新方面的文献。
总结
梅尼埃病是一种内耳疾病，其特征为内耳存在内淋巴积水，以及反复出现且使人衰弱的眩晕发作、耳鸣、耳胀满感和波动性感音神经性听力损失等症状。尽管多年来已提出许多针对梅尼埃病的治疗方案，但科学界尚未达成共识。在过去十年中，提出了许多治疗方案，如鼓室内注射类固醇、鼓室内注射庆大霉素和静脉注射甘油。最近，已对MD患者饮食中抗分泌因子的作用进行了研究。对于难治性MD建议进行手术治疗；一些作者提出了新的方法，包括经耳道内镜下耳蜗下前庭神经切除术、囊手术中的新造瘘术以及镫骨肌和鼓膜张肌切断术。
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