Ximenes Coeli Regina Carneiro, Bergmann Anke, Lima Jurema Telles de Oliveira, Lima Wigna Rayssa Pereira, de Britto Murilo Carlos, de Mello Maria Júlia Gonçalves, Thuler Luiz Claudio Santos
Professor Fernando Figueira Integral Medicine Institute (IMIP), Recife, Brazil.
Research Center, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil.
J Patient Exp. 2020 Dec;7(6):1519-1525. doi: 10.1177/2374373519889246. Epub 2020 Feb 27.
The aim of the present study was to evaluate health-related quality of life (HRQoL) changes at 6 to 12 months after cancer diagnosis and to assess the impact of age in older adults with cancer.
A cohort study using patients ≥60 years old diagnosed with cancer. Health-related quality of life scores were calculated according to the European Organisation for Research and Treatment of Cancer questionnaire. Student's tests for paired samples and a binomial logistic regression were performed.
The study included 241 patients. At diagnosis, the affected HRQoL functions were physical and emotional functions, financial difficulties, pain, and insomnia. At follow-up, cognitive function ( < .001) and dyspnea ( = .004) worsened, while emotional function improved ( = .003).
At the 6 to 12 months of follow-up, older adult cancer patients showed worsening cognitive function and dyspnea and improved emotional function. These HRQoL changes were not associated with age.
本研究旨在评估癌症诊断后6至12个月与健康相关的生活质量（HRQoL）变化，并评估年龄对老年癌症患者的影响。
一项队列研究，使用年龄≥60岁的癌症确诊患者。根据欧洲癌症研究与治疗组织问卷计算与健康相关的生活质量得分。进行配对样本的学生t检验和二项逻辑回归分析。
该研究纳入了241名患者。在诊断时，受影响的HRQoL功能包括身体和情感功能、经济困难、疼痛和失眠。在随访时，认知功能（P<.001）和呼吸困难（P=.004）恶化，而情感功能改善（P=.003）。
在随访的6至12个月时，老年癌症患者的认知功能和呼吸困难恶化，情感功能改善。这些HRQoL变化与年龄无关。
