Institute of Engineering Medicine, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
Tongji University Cancer Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
J Mater Chem B. 2021 Feb 7;9(5):1175-1188. doi: 10.1039/d0tb02745f. Epub 2021 Jan 18.
The use of sensitive electrochemical sensors to detect biomarkers is an effective method for the early diagnosis of several neurodegenerative diseases (NDs), such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, etc. However, the commercialization of enzyme/aptamer-based sensors is still hampered owing to the historic drawbacks of biorecognition elements including high cost, poor stability, and complex integration technology. Non-enzymatic electrochemical sensors are more attractive compared to their traditional counterparts and can be widely harnessed owing to their low cost, high stability, sensitivity, and ease of miniaturization. This review summarizes recent research progress focusing on the construction of non-enzymatic electrochemical sensors and analyzes their present use in the early diagnosis of NDs. Additionally, this review addresses the limitations and challenges of the use of current non-enzymatic electrochemical sensor technologies for the diagnosis of NDs and highlights the possible directions for future research.
利用敏感的电化学传感器来检测生物标志物是早期诊断几种神经退行性疾病（NDs）的有效方法，如阿尔茨海默病、帕金森病、亨廷顿病、肌萎缩性侧索硬化症等。然而，基于酶/适体的传感器的商业化仍然受到生物识别元件的历史缺陷的阻碍，包括高成本、较差的稳定性和复杂的集成技术。与传统的电化学传感器相比，非酶电化学传感器更具吸引力，由于其低成本、高稳定性、灵敏度和易于小型化，可以得到广泛应用。本文综述了近年来非酶电化学传感器构建方面的研究进展，并分析了其在 NDs 早期诊断中的应用。此外，本文还讨论了当前非酶电化学传感器技术在 NDs 诊断中的应用所存在的局限性和挑战，并强调了未来研究的可能方向。
