Emergency & Critical Care and Internal Medicine Departments.
Emergency & Critical Care Department.
J Vet Emerg Crit Care (San Antonio). 2021 May;31(3):414-427. doi: 10.1111/vec.13040. Epub 2021 Jan 17.
To describe the clinical course, treatment, and outcome of 5 dogs following ingestion of toxic Amanita spp. mushrooms containing amatoxins using an adapted version of the Santa Cruz protocol developed for people.
Five dogs were presented with clinical signs compatible with amanitin toxicity with witnessed ingestion noted in 3 of 5 dogs. Clinical findings included acute onset vomiting and diarrhea, lethargy, and hepatopathy including signs of fulminant hepatic failure (increased liver enzyme activities, hyperbilirubinemia, prolonged clotting times, and hypoglycemia were noted among these cases). Urine toxicological screening confirmed the presence of Amanita toxins in 4 cases with expert mycologist speciation in the fifth. Core interventions included percutaneous biliary drainage, use of octreotide, and early nil per os orders. All dogs survived to discharge with this treatment strategy.
This case series describes the use of a modified version of the Santa Cruz protocol to address amatoxin-induced fulminant hepatic failure in dogs. The protocol was safe, well tolerated, and all patients made a full clinical recovery.
描述 5 只因摄入含有鹅膏蕈碱的毒鹅膏菌而出现临床症状的犬的临床经过、治疗和结局，采用的是为人类开发的圣克鲁斯方案的改良版。
5 只犬出现与鹅膏蕈碱毒性一致的临床症状，其中 3 只犬有目击摄入史。临床发现包括急性呕吐和腹泻、嗜睡和肝病，包括暴发性肝衰竭的迹象（这些病例中均观察到肝酶活性升高、高胆红素血症、凝血时间延长和低血糖）。尿液毒理学筛查在 4 例中证实存在鹅膏蕈毒素，第 5 例由专家真菌学家鉴定。核心干预措施包括经皮胆道引流、奥曲肽的使用和早期禁食。所有犬均采用该治疗策略存活至出院。
本病例系列描述了改良版圣克鲁斯方案在治疗犬鹅膏蕈碱诱导的暴发性肝衰竭中的应用。该方案安全、耐受良好，所有患者均完全康复。
