Servicio de Terapia Intensiva del Hospital General de Niños Dr. Pedro de Elizalde (HGNPE), Ciudad Autónoma de Buenos Aires, Argentina.
Arch Argent Pediatr. 2021 Feb;119(1):e26-e35. doi: 10.5546/aap.2021.eng.e26.
Multisystem inflammatory syndrome in children related to COVID-19 is defined as the presence of persistent fever, inflammation, and organ dysfunction, with evidence of past or recent severe acute respiratory syndrome coronavirus 2 infection, and excluding other microbial causes. It overlaps with other inflammatory diseases (Kawasaki disease and toxic shock syndrome) and shares some features with hypercytokinemia conditions (hemophagocytic lymphohistiocytosis and macrophage activation syndrome). It differs from these and severe acute COVID-19 in its clinical presentation and laboratory parameters. It has a potentially severe course and may occur with cardiovascular failure; mortality is low (2 %). Here we provide an update on this syndrome and describe the presentation of two clinical cases with cardiovascular dysfunction who required vasoactive support and invasive ventilation. Serum lab tests showed inflammation parameters. Both patients were treated with intravenous immunoglobulin and systemic corticosteroids and had a favorable course.
与 COVID-19 相关的儿童多系统炎症综合征定义为存在持续发热、炎症和器官功能障碍，并伴有过去或近期严重急性呼吸综合征冠状病毒 2 感染的证据，且排除其他微生物病因。它与其他炎症性疾病（川崎病和中毒性休克综合征）重叠，并与细胞因子过多症（噬血细胞性淋巴组织细胞增多症和巨噬细胞活化综合征）具有一些共同特征。它与这些疾病和严重的急性 COVID-19 在临床表现和实验室参数上有所不同。它具有潜在的严重病程，并可能发生心血管衰竭；死亡率低（2%）。在此，我们对该综合征进行了更新，并描述了两例伴有心血管功能障碍的临床病例，这些病例需要血管活性支持和有创通气。血清实验室检查显示炎症参数。两名患者均接受了静脉注射免疫球蛋白和全身皮质类固醇治疗，病情好转。
