Department of Agro-environmental Sciences, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Nat Prod Res. 2022 Jul;36(14):3610-3618. doi: 10.1080/14786419.2021.1872572. Epub 2021 Jan 18.
-[(3-(3-methyl-1-oxo-butyl)amino)propyl]-3-(3,4-dihydroxyphenyl)prop-2-enamide (), named 'Bassiamide A', a new alkaloid, together with six known compounds including one lignan () and five lignanamides (), were isolated from the aerial parts of Wight. The study also reported an optimal separation of a rare occurring -isomer lignanamide derivative () from a natural origin, in addition to its known corresponding -isomer (). Structures of isolated compounds were elucidated based on NMR spectroscopic data, HR-MS, and comparison with known related ones, and they were identified as syringaresinol (), --feruloyl-3-methoxytyramine (), --feruloyltyramine (), -(-)---feruloyl normetanephrine (), -(-)---feruloyl octopamine (), -(+)---feruloyl octopamine (). The isolated compounds were evaluated for their anti-acetylcholinesterase activity, and they showed weak inhibitory activity.
[(3-(3-甲基-1-氧代丁基)氨基)丙基]-3-(3,4-二羟基苯基)丙-2-烯酰胺（），命名为“Bassiamide A”，是一种新的生物碱，与从 Wight 的地上部分分离得到的六种已知化合物一起，包括一种木脂素（）和五种木脂酰胺（）。该研究还报道了一种罕见的--型异木质酰胺衍生物（）从天然来源中分离出来，除了其已知的相应--型异构体（）。根据 NMR 波谱数据、高分辨率质谱（HR-MS）和与已知相关物质的比较，确定了分离得到的化合物的结构，并将其鉴定为丁香树脂醇（）、--阿魏酰-3-甲氧基酪胺（）、--阿魏酰酪胺（）、-(-)---阿魏酰去甲肾上腺素（）、-(-)---阿魏酰章鱼胺（）、-(+)---阿魏酰章鱼胺（）。对分离得到的化合物进行了抗乙酰胆碱酯酶活性评价，结果表明它们具有较弱的抑制活性。
