Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques, Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, Errachidia, 52000, Morocco.
Faculty of Medicine and Pharmacy of Oujda, Oujda, Morocco.
Rev Recent Clin Trials. 2021;16(3):294-302. doi: 10.2174/1574887116666210114161633.
At the time of writing this paper, no data was available for the clinical and epidemiological characteristics of African patients with COVID-19. Herein, we profiled retrospectively the epidemiological characteristics (clinical, laboratory, radiological, treatment, and clinical outcomes) of 64 confirmed cases of COVID-19 in the Regional Hospital Center (RHC) of Errachidia in Morocco. The aim of this study was to analyze the epidemiological characteristics and laboratory Findings of Covid-19 patients in Errachidia Province, Morocco.
This is a retrospective single-center study that included all COVID-19 confirmed patients (died or discharged) hospitalized in the Regional Center of Errachidia, Morocco, between March 20, 2020 and May 23, 2020. Patients were confirmed by real-time RT-PCR and epidemiological, demographic, clinical, laboratory, treatment, and outcomes of patients were extracted manually from patient's medical records.
In a total of 64 patients with COVID-19, 60.9% of patients were men, with a mean age of 41.5 years (SD 18.62). At the admission, 38 patients were asymptomatic (59.4%), and 58 (90.6%) were clinically classified as being in a benign state. Chronic illnesses were the most comorbidities observed, including diabetes with 8 cases (12.5%), hypertension 3 cases (4.7%), and hyperlipidemia 1 patient (1.6%). The main symptoms were cough 15 (23.4%), fever 10 (15.6), diarrhea 8 (12.5%), headache 5 (7.8%), and sore throat 5 (7.8%). Only 7 patients (10.9%) had lung lesions, and lymphopenia was present in only 7 patients (11.1%). The median duration of viral shedding was 14.5 days (9-22). Concerning deceased cases, they were elderly subjects aged 69.75 years, and they have presented dyspnea, breathing problems, and respiratory distress as specific symptoms. In addition, an increase of the medians of serum AST, CRP, and glucose levels was noticed in this group. During hospitalization, they presented acute respiratory distress syndrome (ARDS), and they were transferred to intensive care before they died.
This study revealed that covid-19 infection often appeared in a benign form in the studied population (90.6% in this study). This finding may incriminate the implication of some protective parameters such as genetic, nutritional or other factors in the Moroccan population.
在撰写本文时，尚无关于非洲 COVID-19 患者临床和流行病学特征的数据。在此，我们回顾性分析了摩洛哥厄拉奇迪亚地区中心医院（RHC）确诊的 64 例 COVID-19 患者的流行病学特征（临床、实验室、影像学、治疗和临床结局）。本研究旨在分析摩洛哥厄拉奇迪亚省 COVID-19 患者的流行病学特征和实验室发现。
这是一项回顾性单中心研究，纳入了 2020 年 3 月 20 日至 5 月 23 日期间在摩洛哥厄拉奇迪亚地区中心医院住院的所有 COVID-19 确诊患者（死亡或出院）。患者通过实时 RT-PCR 确诊，从患者病历中手动提取流行病学、人口统计学、临床、实验室、治疗和患者结局等信息。
在总共 64 例 COVID-19 患者中，60.9%为男性，平均年龄为 41.5 岁（标准差 18.62）。入院时，38 例为无症状患者（59.4%），58 例（90.6%）临床分类为良性。最常见的合并症是糖尿病 8 例（12.5%）、高血压 3 例（4.7%）和高脂血症 1 例（1.6%）。主要症状为咳嗽 15 例（23.4%）、发热 10 例（15.6%）、腹泻 8 例（12.5%）、头痛 5 例（7.8%）和咽痛 5 例（7.8%）。仅有 7 例（10.9%）患者有肺部病变，仅有 7 例（11.1%）患者有淋巴细胞减少症。病毒脱落的中位数持续时间为 14.5 天（9-22 天）。关于死亡病例，他们是 69.75 岁的老年患者，表现为呼吸困难、呼吸问题和呼吸窘迫等特定症状。此外，该组患者的血清 AST、CRP 和葡萄糖水平中位数升高。住院期间，他们出现急性呼吸窘迫综合征（ARDS），并在死亡前转至重症监护病房。
本研究表明，COVID-19 感染在研究人群中通常表现为良性形式（本研究中为 90.6%）。这一发现可能表明在摩洛哥人群中存在一些保护性参数的作用，如遗传、营养或其他因素。
