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来自新德里一家 COVID-19 指定医院的 SARS-CoV-2 疾病患者的临床特征和流行病学特征。

Clinical characteristic and epidemiological features of SARS CoV-2 disease patients from a COVID-19 designated hospital in New Delhi.

机构信息

Department of Microbiology, Maulana Azad Medical College, New Delhi, India.

Lok Nayak Hospital, New Delhi, India.

出版信息

J Med Virol. 2021 Apr;93(4):2487-2492. doi: 10.1002/jmv.26777. Epub 2021 Jan 22.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) infection is rapidly evolving as a serious global pandemic. The present study describes the clinical characteristics of SARS CoV-2 infection patients. The samples were subjected to reverse-transcription polymerase chain reaction or Rapid Antigen test for diagnosis of SARS CoV-2. A cohort of 3745 patients with confirmed diagnosis of SARS CoV-2 infection in a tertiary care center in New Delhi, India were included in this study. Data were collected from offline and online medical records over a period of 6 months. Amongst 3745 SARS CoV-2 infected patients, 2245 (60%) were symptomatic and 1500 (40%) were asymptomatic. Most common presenting symptom was cough (49.3%) followed febrile episodes (47.1%), breathlessness (42.7%), and sore throat (35.1%). Cough along with breathlessness (24.1) was the most common combination of symptoms followed by fever with cough (22.7). The most common comorbidity found among symptomatic group was diabetes (42.5%) followed by hypertension (21.4%) and chronic kidney disease (18%). Comorbidities like diabetes mellitus, chronic diseases of lungs, heart, and kidneys were found to be common in symptomatic group and this was found to be statistically significant (p < .05). COVID-19 is an evolving disease and data from our study help in understanding the clinic-epidemiological profile of patients.

摘要

严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)感染迅速演变为严重的全球大流行。本研究描述了 SARS-CoV-2 感染患者的临床特征。对样本进行逆转录聚合酶链反应或快速抗原检测以诊断 SARS-CoV-2。本研究纳入了印度新德里一家三级保健中心确诊的 3745 例 SARS-CoV-2 感染患者。数据来自 6 个月期间的离线和在线病历。在 3745 例 SARS-CoV-2 感染患者中,2245 例(60%)有症状,1500 例(40%)无症状。最常见的首发症状是咳嗽(49.3%),其次是发热(47.1%)、呼吸急促(42.7%)和喉咙痛(35.1%)。咳嗽伴呼吸急促(24.1%)是最常见的症状组合,其次是发热伴咳嗽(22.7%)。在有症状组中最常见的合并症是糖尿病(42.5%),其次是高血压(21.4%)和慢性肾脏病(18%)。在有症状组中发现合并糖尿病、肺部、心脏和肾脏的慢性疾病很常见,这具有统计学意义(p<0.05)。COVID-19 是一种不断演变的疾病,本研究的数据有助于了解患者的临床流行病学特征。

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