Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, C.P. 36050, Guanajuato, Guanajuato, México.
Future Microbiol. 2021 Jan;16(2):107-118. doi: 10.2217/fmb-2020-0158. Epub 2021 Jan 18.
Viruses have caused the death of millions of people worldwide. Specifically, human viruses are grouped into 21 families, including the family of coronaviruses (CoVs). In December 2019, in Wuhan, China, a new human CoV was identified, SARS-CoV-2. The first step of the infection mechanism of the SARS-CoV-2 in the human host is adhesion, which occurs through the S glycoprotein that is found in diverse human organs. Another way through which SARS-CoV-2 could possibly attach to the host's cells is by means of the histo-blood group antigens. In this work, we have reviewed the mechanisms by which some viruses bind to the histo-blood group antigens, which could be related to the susceptibility of the individual and are dependent on the histo-blood group.
病毒已在全球范围内导致数百万人死亡。具体而言，人类病毒被分为 21 个家族，其中包括冠状病毒科（CoVs）。2019 年 12 月，在中国武汉，发现了一种新型人类冠状病毒，即 SARS-CoV-2。SARS-CoV-2 在人体宿主中感染机制的第一步是黏附，这是通过在多种人体器官中发现的 S 糖蛋白发生的。SARS-CoV-2 可能附着于宿主细胞的另一种方式是通过组织血型抗原。在这项工作中，我们回顾了一些病毒与组织血型抗原结合的机制，这些机制可能与个体的易感性有关，并依赖于组织血型。
