John Hunter Hospital and The University of Newcastle, Newcastle, Australia.
IRCCS San Raffaele Scientific Institute, Department of Clinical Neurosciences, Neurology-Sleep Disorder Center, Milan, Italy.
J Alzheimers Dis. 2021;80(1):29-40. doi: 10.3233/JAD-201066.
Obstructive sleep apnea (OSA) and Alzheimer's disease (AD) are two common chronic diseases with a well-documented association. Whether the association is causal has been highlighted by recent evidence reporting a neurobiological link between these disorders. This narrative review discusses the brain regions and networks involved in OSA as potential vulnerable areas for the development of AD neuropathology with a particular focus on gender-related implications. Using a neuroimaging perspective supported by neuropathological investigations, we provide a new model of neurodegeneration common to OSA and AD, that we have called OSA-AD neurodegeneration in order to decode the causal links between these two chronic conditions.
阻塞性睡眠呼吸暂停（OSA）和阿尔茨海默病（AD）是两种常见的慢性疾病，它们之间存在明确的关联。最近的证据报告称，这两种疾病之间存在神经生物学联系，这凸显了这种关联是否具有因果关系。本文综述讨论了 OSA 相关的脑区和网络，认为这些区域和网络可能是 AD 神经病理学发展的脆弱区域，并特别关注了性别相关的影响。我们采用神经影像学的观点，并结合神经病理学的研究，提出了一个新的 OSA 和 AD 共有的神经退行性变模型，我们称之为 OSA-AD 神经退行性变，旨在解码这两种慢性疾病之间的因果关系。
