Department of Neurology, University Hospital of Besançon, Besançon, France.
Clinical and Integrative Neuroscience, Research Laboratory 481, Bourgogne Franche-Comté University, Besançon, France.
J Alzheimers Dis. 2021;79(4):1397-1407. doi: 10.3233/JAD-201207.
Neurodevelopmental and neurodegenerative disorders are both growing major public health topics with similarities and frequent complex interactions with each other. Taking these aspects into account can provide a new point of view on lifelong neurocognitive trajectories. Assessing both neurodevelopmental and neurodegenerative dimensions during cognitive and behavioral clinical assessments is challenging but might improve diagnostic accuracy and physiopathological understanding. It is therefore necessary to understand the lifelong specific neurocognitive trajectory of each patient in order to develop personalized precision cognitive medicine.
神经发育和神经退行性疾病都是日益严重的主要公共卫生问题，它们之间存在相似之处，并且经常相互复杂地相互作用。考虑到这些方面，可以为终生神经认知轨迹提供新的视角。在认知和行为临床评估中同时评估神经发育和神经退行性维度具有挑战性，但可能会提高诊断准确性和病理生理学理解。因此，有必要了解每个患者的终生特定神经认知轨迹，以便开发个性化精准认知医学。
