University of Michigan School of Medicine, Department of Neurology, Division of Neuromuscular Medicine, Ann Arbor, MI, USA.
Ohio State University Wexner Medical Center, Department of Neurology, Division of Neuromuscular Medicine, Columbus, OH, USA.
J Neuromuscul Dis. 2021;8(2):299-303. doi: 10.3233/JND-200581.
The prognostic value of cerebrospinal fluid (CSF) protein in Guillain Barré Syndrome (GBS) is unclear. We aimed to explore the potential association between CSF protein level and mechanical ventilation in GBS. We undertook a retrospective study of GBS patients from January 2000 to November 2019 at the University of Michigan. 94 patients were ultimately included for evaluation. After adjusting for the Erasmus GBS Respiratory Insufficiency Scale (EGRIS), we did not find a significant difference in CSF protein between ventilated and non-ventilated patients. Elevated CSF protein level does not appear to portend an increased likelihood of mechanical ventilation in GBS patients.
脑脊液（CSF）蛋白在吉兰-巴雷综合征（GBS）中的预后价值尚不清楚。我们旨在探讨 CSF 蛋白水平与 GBS 机械通气之间的潜在关联。我们对 2000 年 1 月至 2019 年 11 月在密歇根大学就诊的 GBS 患者进行了回顾性研究。最终有 94 例患者纳入评估。在调整了 Erasmus GBS 呼吸功能不全量表（EGRIS）后，我们没有发现通气和非通气患者的 CSF 蛋白水平有显著差异。升高的 CSF 蛋白水平似乎不会预示 GBS 患者机械通气的可能性增加。
