Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio, USA.
Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, USA.
Proteomics. 2021 May;21(9):e2000121. doi: 10.1002/pmic.202000121. Epub 2021 Feb 23.
Caloric restriction (CR) is an innovative therapy used in tumor tissue and tumor model studies to promote cell death and decrease cell viability. Caloric restriction mimetics (CRMs) are a class of drugs that induce CR and starvation conditions within a cell. When used simultaneously with other chemotherapy agents, the effects are synergistic and effective at promoting tumor cell death. In this review, we discuss CRMs and their potential as cancer therapeutics. Firstly, we establish an overview of CR and its impacts on healthy and tumor cells. CR and CRM drugs have shown to decrease age-related diseases and can act as an anti-cancer agent. As it can be challenging for an individual to diligently stick to a diet that would induce CR, CRMs are even more desirable. Then, we discuss the drug class by highlighting three CRMs: resveratrol, (-)-hydroxycitric acid, and rapamycin. These CRMs are commonly known for their dietary effects, but the underlying mechanisms that drive cellular metabolic and proteomic changes show promise as a cancer therapeutic. Lastly, we highlight the use of mass spectrometry and proteomic techniques on experiments utilizing CRM drugs to understand the cellular pathways impacted by this drug class, leading to a better understanding of the anti-cancer properties and potentials of CRM.
热量限制（CR）是一种创新性的治疗方法，用于肿瘤组织和肿瘤模型研究中，以促进细胞死亡和降低细胞活力。热量限制模拟物（CRMs）是一类能诱导细胞内 CR 和饥饿状态的药物。当与其他化疗药物同时使用时，其效果具有协同作用，能有效促进肿瘤细胞死亡。在这篇综述中，我们讨论了 CRMs 及其作为癌症治疗剂的潜力。首先，我们建立了 CR 及其对健康细胞和肿瘤细胞影响的概述。CR 和 CRM 药物已被证明可以减少与年龄相关的疾病，并且可以作为抗癌剂。由于个体很难坚持进行诱导 CR 的饮食，因此 CRMs 更受欢迎。然后，我们通过突出三种 CRMs：白藜芦醇、（-）-羟基柠檬酸和雷帕霉素来讨论药物类别。这些 CRMs 通常因其饮食作用而闻名，但驱动细胞代谢和蛋白质组变化的潜在机制显示出作为癌症治疗剂的潜力。最后，我们强调了在利用 CRM 药物进行的实验中使用质谱和蛋白质组学技术，以了解该药物类别影响的细胞途径，从而更好地理解 CRM 的抗癌特性和潜力。
