Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Natural Science and Environment, Roskilde University, Roskilde, Denmark.
Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
Environ Res. 2021 Apr;195:110739. doi: 10.1016/j.envres.2021.110739. Epub 2021 Jan 15.
Previous studies have suggested that transportation noise may increase risk for breast cancer, but existing literature is scarce and inconclusive. We aimed to investigate associations between road traffic and railway noise and risk for breast cancer across the entire Danish female population.
For all 2.8 million residential addresses across Denmark, we modelled road and railway noise at the most and least exposed façades for the period 1990-2017. We calculated 10-year time-weighted mean noise exposure for 1.8 million women aged >35 years, of whom 66,006 developed breast cancer during follow-up from 2000 to 2017. We analysed data using Cox proportional hazards models with noise exposure included as 10-year running means and adjusted for a number of individual and area-level socioeconomic co-variates and air pollution with fine particles estimated for all addresses.
For exposures at the least exposed façade, we found that a 10 dB increase in 10-year time-weighted noise was associated with incidence rate ratios (IRRs) and 95% confidence intervals (CI) for breast cancer of 1.032 (1.019-1.046) for road noise and 1.023 (0.993-1.053) for railway noise. For exposures at the most exposed façade, the IRRs (95% CIs) were 1.012 (1.002-1.022) for road noise and 1.020 (1.001-1.039) for railway noise. Associations were strongest among women with human epidermal growth factor receptor 2 negative breast cancer.
Road traffic and railway noise were associated with higher risk for breast cancer, especially noise at the least exposed façade, which is a proxy for noise exposure during sleep.
先前的研究表明，交通噪声可能会增加乳腺癌的风险，但现有文献很少且结果不一致。我们旨在调查丹麦全部女性人群中道路交通和铁路噪声与乳腺癌风险之间的关联。
对于丹麦各地的 280 万个住宅地址，我们在 1990-2017 年期间针对最暴露和最不暴露的外墙建立了道路交通和铁路噪声模型。我们计算了 180 万名年龄大于 35 岁的女性的 10 年时间加权平均噪声暴露量，其中 66006 人在 2000 年至 2017 年的随访期间患上了乳腺癌。我们使用 Cox 比例风险模型分析数据，将噪声暴露作为 10 年的运行平均值，并根据个人和区域社会经济协变量以及所有地址的细颗粒物估计的空气污染进行了调整。
对于最不暴露外墙的暴露，我们发现 10 年时间加权噪声增加 10dB，与乳腺癌的发病率比（IRR）及其 95%置信区间（CI）相关，道路交通噪声的 IRR（95%CI）为 1.032（1.019-1.046），铁路噪声为 1.023（0.993-1.053）。对于最暴露外墙的暴露，道路交通噪声的 IRR（95%CI）为 1.012（1.002-1.022），铁路噪声为 1.020（1.001-1.039）。这些关联在人表皮生长因子受体 2 阴性乳腺癌女性中最强。
道路交通和铁路噪声与乳腺癌风险增加相关，尤其是最不暴露外墙的噪声，这是睡眠期间噪声暴露的代表。
