用针对中毒性休克综合征（TSS）毒素-1的单克隆抗体在TSS感染模型中保护兔子。
Protection of rabbits in an infection model of toxic shock syndrome (TSS) by a TSS toxin-1-specific monoclonal antibody.
作者信息
Best G K, Scott D F, Kling J M, Thompson M R, Adinolfi L E, Bonventre P F
机构信息
Department of Cell and Molecular Biology, Medical College of Georgia, Augusta 30912.
出版信息
Infect Immun. 1988 Apr;56(4):998-9. doi: 10.1128/iai.56.4.998-999.1988.
Abstract
An anti-TSST-1-specific monoclonal antibody (MAb 8-5-7) was tested for its protective capacity in a rabbit infection model to toxic shock syndrome (TSS). The challenge strain of Staphylococcus aureus (RN4710), which contained a plasmid encoding TSS toxin-1, was introduced into previously implanted chambers. Purified monoclonal antibody (1.25 mg of immunoglobulin G) administered parenterally 1 day before and 1 day after initiation of infection provided complete protection against the TSS-like syndrome and the mortality which occurred in unprotected rabbits.
摘要
一种抗中毒性休克综合征毒素-1（TSST-1）特异性单克隆抗体（单克隆抗体8-5-7）在兔感染模型中针对中毒性休克综合征（TSS）的保护能力进行了测试。将含有编码TSS毒素-1质粒的金黄色葡萄球菌攻击菌株（RN4710）引入先前植入的腔室。在感染开始前1天和开始后1天经肠胃外给予纯化的单克隆抗体（1.25mg免疫球蛋白G），可完全预防未受保护兔子中出现的TSS样综合征和死亡。
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