Best G K, Scott D F, Kling J M, Crowell W F, Kirkland J J
Infect Immun. 1984 Dec;46(3):727-32. doi: 10.1128/iai.46.3.727-732.1984.
Artificial infection chambers in rabbits were infected with a toxic shock strain of Staphylococcus aureus in an attempt to determine the nature of the enhanced virulence of toxic shock strains relative to non-toxic shock strains of staphylococci. The results showed that rabbits immunized with either neutral or acidic proteins were protected from the lethal effects of these infections. Male rabbits were found to be significantly more susceptible to these infections than female rabbits. Castration rendered both sexes equally susceptible to lethal infections. Numerous tissues from all infected rabbits were examined histologically, and most of the pathological findings involved lymphoid tissue. Of special interest was the observation that unprotected male rabbits which died had evidence of lymphoid depletion and that surviving rabbits, both male and female, usually manifested lymphoid hyperplasia. No other pathological response was noted which would characterize these infections, but immunized rabbits had a diminished level of thymic cortex involution that was not different between the sexes.
用金黄色葡萄球菌中毒性休克菌株感染兔人工感染室，试图确定中毒性休克菌株相对于葡萄球菌无毒休克菌株增强毒力的性质。结果表明，用中性或酸性蛋白质免疫的兔对这些感染的致死作用具有抵抗力。发现雄性兔比雌性兔对这些感染的易感性明显更高。阉割使两性对致死性感染的易感性相同。对所有感染兔的许多组织进行了组织学检查，大多数病理发现都涉及淋巴组织。特别值得注意的是，未受保护而死亡的雄性兔有淋巴组织耗竭的证据，而存活的兔，无论雄性还是雌性，通常表现为淋巴组织增生。未观察到其他可表征这些感染的病理反应，但免疫兔的胸腺皮质退化水平降低，两性之间无差异。
