Parving H H, Noer J, Kehlet H, Mogensen C E, Svendsen P A, Heding L
Diabetologia. 1977 Aug;13(4):323-5. doi: 10.1007/BF01223273.
Kidney function was studied in six normal males before and during a 2 h glucagon (10 ng/kg/min) infusion. The following variables were determined during each 20 min clearance period; glomerular filtration rate (GFR), renal plasma-flow (RPF) , filtration fraction (FF), urinary albumin and beta2-microglobulin-excretion rates. Glucagon infusion resulted in a fourfold increase in plasma glucagon concentration. The infusion induced a significant increase in GFR (+9%), FF (+9%) and urinary beta2-microglobulin excretion rate (+32%), (p less than 0.01). RPF and urinary albumin excretion rates were not significantly changed. We suggest that glucagon may contribute to the reversible kidney function alterations typically found in poorly regulated juvenile diabetes, a state with relative or absolute hyperglucagonaemia.
在六名正常男性输注胰高血糖素（10纳克/千克/分钟）之前及输注过程中的2小时内，对其肾功能进行了研究。在每个20分钟的清除期测定了以下变量：肾小球滤过率（GFR）、肾血浆流量（RPF）、滤过分数（FF）、尿白蛋白和β2-微球蛋白排泄率。输注胰高血糖素导致血浆胰高血糖素浓度增加了四倍。输注引起GFR（+9%）、FF（+9%）和尿β2-微球蛋白排泄率（+32%）显著增加（p<0.01）。RPF和尿白蛋白排泄率无显著变化。我们认为，胰高血糖素可能导致了青少年糖尿病患者（一种相对或绝对高胰高血糖素血症状态）中典型的可逆性肾功能改变。
