• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

替兰地地津，一种新型的替兰霉素-链霉溶菌素型四嗪酸。II. 分离与结构表征。

Tirandalydigin, a novel tetramic acid of the tirandamycin-streptolydigin type. II. Isolation and structural characterization.

作者信息

Brill G M, McAlpine J B, Whittern D

机构信息

Abbott Laboratories, Abbott Park, Illinois 60064.

出版信息

J Antibiot (Tokyo). 1988 Jan;41(1):36-44. doi: 10.7164/antibiotics.41.36.

DOI:10.7164/antibiotics.41.36
PMID:3346191
Abstract

Tirandalydigin a structurally unique hybrid of the tirandamycin-streptolydigin families of tetramic acid antibiotics has been isolated from the fermentation beers of Streptomyces sp. AB-1006A-9. The structure of this anti-anaerobic antibiotic has been characterized based upon NMR, UV and mass spectrometric data.

摘要

替兰地地菌素是从链霉菌属AB - 1006A - 9的发酵液中分离得到的，它是结构独特的四胺酸抗生素替兰霉素-链霉溶菌素家族的杂合体。这种抗厌氧菌抗生素的结构已通过核磁共振、紫外和质谱数据得以表征。

相似文献

1
Tirandalydigin, a novel tetramic acid of the tirandamycin-streptolydigin type. II. Isolation and structural characterization.替兰地地津，一种新型的替兰霉素-链霉溶菌素型四嗪酸。II. 分离与结构表征。
J Antibiot (Tokyo). 1988 Jan;41(1):36-44. doi: 10.7164/antibiotics.41.36.
2
Tirandalydigin, a novel tetramic acid of the tirandamycin-streptolydigin type. I. Taxonomy of the producing organism, fermentation and biological activity.
J Antibiot (Tokyo). 1992 Jul;45(7):1125-32. doi: 10.7164/antibiotics.45.1125.
3
Isolation, characterization and structures of PA-46101 A and B.PA - 46101 A和B的分离、表征及结构
J Antibiot (Tokyo). 1990 Jul;43(7):739-47. doi: 10.7164/antibiotics.43.739.
4
The use of doubly-labeled 13C-acetate in the study of streptolydigin biosynthesis.
J Antibiot (Tokyo). 1983 Nov;36(11):1536-8. doi: 10.7164/antibiotics.36.1536.
5
Phenelfamycins, a novel complex of elfamycin-type antibiotics. II. Isolation and structure determination.苯乙霉素，一种新型的埃弗霉素类抗生素复合物。II. 分离与结构测定。
J Antibiot (Tokyo). 1988 Oct;41(10):1300-15. doi: 10.7164/antibiotics.41.1300.
6
The structure of CP-80,219, a new polyether antibiotic related to dianemycin.
J Antibiot (Tokyo). 1990 Jun;43(6):727-30. doi: 10.7164/antibiotics.43.727.
7
A novel series of milbemycin antibiotics from Streptomyces strain E225. II. Isolation, characterization, structure elucidation and solution conformations.
J Antibiot (Tokyo). 1990 Sep;43(9):1069-76. doi: 10.7164/antibiotics.43.1069.
8
Tirandamycin, an inhibitor of bacterial ribonucleic acid polymerase.替兰霉素，一种细菌核糖核酸聚合酶抑制剂。
Antimicrob Agents Chemother. 1976 Oct;10(4):618-22. doi: 10.1128/AAC.10.4.618.
9
CP-60,993, a new dianemycin-like ionophore produced by Streptomyces hygroscopicus ATCC 39305: fermentation, isolation and characterization.CP-60,993，一种由吸水链霉菌ATCC 39305产生的新型类双霉素离子载体：发酵、分离与表征
J Ind Microbiol. 1990 Aug;5(6):365-74. doi: 10.1007/BF01578095.
10
New antibiotic U-64846: fermentation, isolation and characterization.新型抗生素U-64846：发酵、分离与特性研究
J Antibiot (Tokyo). 1984 Feb;37(2):96-102. doi: 10.7164/antibiotics.37.96.

引用本文的文献

1
Synthesis of Chiral Tetramic Acids: Preparation of ()-5-Benzylpyrrolidine-2,4-dione from L-Phenylalanine Methyl Ester Hydrochloride.手性四氢吡咯酸的合成：由L-苯丙氨酸甲酯盐酸盐制备（）-5-苄基吡咯烷-2,4-二酮。
Organic Synth. 2019;96:528-585. doi: 10.15227/orgsyn.096.0528.
2
Thiol Probes To Detect Electrophilic Natural Products Based on Their Mechanism of Action.基于作用机制检测亲电天然产物的硫醇探针
ACS Chem Biol. 2016 Aug 19;11(8):2328-36. doi: 10.1021/acschembio.5b00924. Epub 2016 Jun 28.
3
A New Analogue of Echinomycin and a New Cyclic Dipeptide from a Marine-Derived Streptomyces sp. LS298.
一种来自海洋链霉菌LS298的棘霉素新类似物和一种新的环二肽。
Mar Drugs. 2015 Nov 18;13(11):6947-61. doi: 10.3390/md13116947.
4
Chemical synthesis enables biochemical and antibacterial evaluation of streptolydigin antibiotics.化学合成使链霉溶菌素抗生素的生化和抗菌评估成为可能。
J Am Chem Soc. 2011 Aug 10;133(31):12172-84. doi: 10.1021/ja2041964. Epub 2011 Jul 20.
5
Isolation and characterization of tirandamycins from a marine-derived Streptomyces sp.从海洋来源的链霉菌属菌株中分离和鉴定替兰霉素
J Nat Prod. 2009 Nov;72(11):2076-9. doi: 10.1021/np9005597.