PA - 46101 A和B的分离、表征及结构

Isolation, characterization and structures of PA-46101 A and B.

作者信息

Matsumoto M, Kawamura Y, Yoshimura Y, Terui Y, Nakai H, Yoshida T, Shoji J

机构信息

Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.

出版信息

J Antibiot (Tokyo). 1990 Jul;43(7):739-47. doi: 10.7164/antibiotics.43.739.

DOI:10.7164/antibiotics.43.739

PMID:2387767

Abstract

New antibiotics, PA-46101 A and B, were isolated from the culture broth of a Streptomycete. The molecular formulae of A and B were determined to be C52H70O18 and C61H86O22, respectively, by elemental analyses, NMR and mass spectrometry. Their structures were elucidated by X-ray crystallography and NMR spectroscopy. These antibiotics are active in vitro against anaerobic Gram-positive and Gram-negative bacteria and also against a limited number of aerobic Gram-positive bacteria.

摘要

新型抗生素PA - 46101 A和B是从链霉菌的培养液中分离出来的。通过元素分析、核磁共振和质谱分析确定，A和B的分子式分别为C52H70O18和C61H86O22。它们的结构通过X射线晶体学和核磁共振光谱得以阐明。这些抗生素在体外对厌氧革兰氏阳性菌和革兰氏阴性菌有活性，对有限数量的需氧革兰氏阳性菌也有活性。