Ali Zakiullah, Zakian Christian, Li Qian, Gloriod Jerome, Crozat Sophie, Bouvet François, Pierre Guillaume, Sarantos Vassilis, Di Pietro Massimiliano, Flisikowski Krzysztof, Andersen Peter, Drexler Wolfgang, Ntziachristos Vasilis
Chair of Biological Imaging, Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.
Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.
Photoacoustics. 2022 Feb 1;25:100333. doi: 10.1016/j.pacs.2022.100333. eCollection 2022 Mar.
Gastrointestinal (GI) endoscopy is a common medical diagnostic procedure used for esophageal cancer detection. Current emerging capsule optoacoustic endoscopes, however, suffer from low pulse repetition rates and slow scanning units limit attainable imaging frame rates. Consequently, motion artifacts result in inaccurate spatial mapping and misinterpretation of data. To overcome these limitations, we report a 360, 50 Hz frame rate, distal scanning capsule optoacoustic endoscope. The translational capability of the instrument for human GI tract imaging was characterized with an Archimedean spiral phantom consisting of twelve 100 µm sutures, a stainless steel mesh with a pitch of 3 mm and an pig esophagus sample. We estimated an imaging penetration depth of ~0.84 mm in vivo by immersing the mesh phantom in intralipid solution to simulate light scattering in human esophageal tissue and validated our findings using pig esophagus. This proof-of-concept study demonstrates the translational potential of the proposed video-rate endoscope for human GI tract imaging.
胃肠道（GI）内窥镜检查是一种用于食管癌检测的常见医学诊断程序。然而，目前新兴的胶囊光声内窥镜存在脉冲重复率低和扫描单元速度慢的问题，限制了可达到的成像帧率。因此，运动伪影会导致空间映射不准确和数据解读错误。为了克服这些限制，我们报告了一种360度、50赫兹帧率的远端扫描胶囊光声内窥镜。该仪器用于人体胃肠道成像的平移能力通过一个由十二根100微米缝线、间距为3毫米的不锈钢网和一个猪食管样本组成的阿基米德螺旋体模进行了表征。我们通过将网状体模浸入脂质乳剂溶液中来模拟人体食管组织中的光散射，估计了体内成像穿透深度约为0.84毫米，并使用猪食管验证了我们的发现。这项概念验证研究证明了所提出的视频速率内窥镜用于人体胃肠道成像的转化潜力。
