Department of Chemistry, Indian Institute of Technology Delhi (IIT Delhi), Hauz Khas, New Delhi, 110016, India.
Kusuma School of Biological Sciences, Indian Institute of Technology Delhi (IIT Delhi), Hauz Khas, New Delhi, 110016, India.
Angew Chem Int Ed Engl. 2020 Nov 23;59(48):21377-21381. doi: 10.1002/anie.202004551. Epub 2020 Sep 18.
The biological applications of germylenes remain unrealised owing to their unstable nature. We report the isolation of air-, water-, and culture-medium-stable germylene DPMGeOH (3; DPM=dipyrromethene ligand) and its potential biological application. Compound 3 exhibits antiproliferative effects comparable to that of cisplatin in human cancer cells. The cytotoxicity of compound 3 on normal epithelial cells is minimal and is similar to that of the currently used anticancer drugs. These findings provide a framework for a plethora of biological studies using germylenes and have important implications for low-valent main-group chemistry.
由于其不稳定的性质，锗烯的生物应用仍然没有实现。我们报告了空气稳定、水稳定和培养基稳定的锗烯 DPMGeOH（3；DPM=二吡咯甲烷配体）的分离及其潜在的生物学应用。化合物 3 在人类癌细胞中表现出与顺铂相当的抗增殖作用。化合物 3 对正常上皮细胞的细胞毒性最小，与目前使用的抗癌药物相似。这些发现为使用锗烯进行大量生物学研究提供了框架，并对低价主族化学具有重要意义。
