Private practice, Tientsin, China.
Privacte practice, Chengdu, China.
J Biol Regul Homeost Agents. 2021 Jan-Feb;35(1 Suppl. 1):55-62.
Helicobacter pylori bacteria (HPB) is one of the most common gastric infections in the world. It seems that HPB infects the subject early in life and is transmitted from person to person. The oral cavity could be a reservoir of HPB participating in infection transmission. HPB and recurrent aphthous stomatitis (RAS) show similar clinical and histological findings, and the discovery of HPB in RAS ulcers support the idea of a correlation between the two diseases. Another important relationship between RAS and HPB is the high incidence of anemia in patients with RAS that may be caused by HPB. In fact, antibiotic therapy and treatment of anemia can reduce the frequency of RAS ulcer recurrence. HPB is considered a carcinogenic agent type 1 of the stomach. In conclusion, the oral cavity is an extra-gastric reservoir of HPB and periodontal therapy associated with systemic therapy can better eradicate HPB from the mucosa of all gastro-enteric tract. Prospective cohort studies are needed to demonstrate the bacterial action in the oral cavity.
幽门螺杆菌（HPB）是世界上最常见的胃部感染细菌之一。它似乎在生命早期感染宿主，并在人与人之间传播。口腔可能是参与感染传播的 HPB 的储库。HPB 和复发性阿弗他口炎（RAS）具有相似的临床和组织学表现，在 RAS 溃疡中发现 HPB 支持这两种疾病之间存在相关性的观点。RAS 和 HPB 之间的另一个重要关系是 RAS 患者贫血的发生率很高，这可能是由 HPB 引起的。事实上，抗生素治疗和贫血治疗可以降低 RAS 溃疡复发的频率。HPB 被认为是胃的 1 型致癌剂。总之，口腔是 HPB 的胃外储库，牙周治疗联合全身治疗可以更好地从所有胃肠道黏膜中根除 HPB。需要前瞻性队列研究来证明口腔中的细菌作用。
