Luo Xiang, Zhang Jun, Wu Yan-Ping, Yang Xiaohan, Kuang Xiu-Ping, Li Wei-Xi, Li Yi-Fang, He Rong-Rong, Liu Mingxian
Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China.
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China.
ACS Biomater Sci Eng. 2020 Jun 8;6(6):3361-3374. doi: 10.1021/acsbiomaterials.9b01709. Epub 2020 May 27.
Multifunctional nanoparticles for imaging and treatment in cancer are getting more and more attention recently. Herein, halloysite nanotubes (HNTs), natural clay nanotubes, are designed as multifunctional nanoplatform for targeted delivering photothermal therapy agents and chemotherapeutic drugs. FeO was anchored on the outer surfaces of HNTs and then doxorubicin (DOX) was loaded on the nanotubes. Afterward, a layer of polypyrrole (PPy), as photothermal agent, was wrapped on the tubes. The nanoplatform of HNT@FeO@PPy@DOX can be guided to tumor tissue by an external magnetic field, and then performs chemo-photothermal combined therapy by 808 nm laser irradiation. HNT@FeO@PPy@DOX shows the ability of -weighted magnetic resonance imaging, which could be considered as a promising application in magnetic targeting tumor therapy. In vitro and in vivo experiments demonstrate that HNTs nanoplatform has good biocompatibility and produces a strong antitumor effect trigged by near-infrared laser irradiation. The novel chemo-photothermal therapy nanoplatform based on HNTs may be developed as a multifunctional nanoparticle for imaging and therapy in breast cancer.
近年来，用于癌症成像和治疗的多功能纳米粒子越来越受到关注。在此，埃洛石纳米管（HNTs），即天然粘土纳米管，被设计为用于靶向递送光热治疗剂和化疗药物的多功能纳米平台。将FeO锚定在HNTs的外表面，然后将阿霉素（DOX）负载到纳米管上。随后，在纳米管上包裹一层作为光热剂的聚吡咯（PPy）。HNT@FeO@PPy@DOX纳米平台可通过外部磁场引导至肿瘤组织，然后通过808nm激光照射进行化疗-光热联合治疗。HNT@FeO@PPy@DOX具有T2加权磁共振成像能力，这可被视为在磁靶向肿瘤治疗中的一个有前景的应用。体外和体内实验表明，HNTs纳米平台具有良好的生物相容性，并通过近红外激光照射产生强大的抗肿瘤效果。基于HNTs的新型化疗-光热治疗纳米平台可能被开发为用于乳腺癌成像和治疗的多功能纳米粒子。
