Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan 81746-73441, Iran.
Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Stanford, California 94305, United States.
ACS Biomater Sci Eng. 2020 May 11;6(5):2726-2739. doi: 10.1021/acsbiomaterials.9b01987. Epub 2020 Apr 28.
Various subtypes of immunocytes react against implanted biomaterials to eliminate the foreign body object from the host's body. Among these cells, dendritic cells (DCs) play a key role in early immune response, later engaging lymphocytes through antigens presentation. Due to their capability to induce tolerogenic or immunogenic responses, DCs have been considered as key therapeutic targets for immunomodulatory products. For instance, tolerogenic DCs are applied in the treatment of autoimmune diseases, rejection of allograft transplantation, and implanted biomaterial. Due to the emerging importance of DCs in immunomodulatory biomaterials, this Review summarizes DCs' responses-such as adhesion, migration, and maturation-to biomaterials. We also review some examples of key molecules and their applications in DCs' immunoengineering. These evaluations would pave the way for designing advanced biomaterials and nanomaterials to modulate the immune system, applicable in tissue engineering, transplantation, and drug delivery technologies.
各种免疫细胞亚型对抗植入的生物材料，以将异物从宿主体内清除。在这些细胞中，树突状细胞 (DCs) 在早期免疫反应中发挥关键作用，通过抗原呈递来激活淋巴细胞。由于其诱导耐受或免疫原性反应的能力，DCs 已被视为免疫调节产品的关键治疗靶点。例如，耐受型 DCs 应用于自身免疫性疾病、同种异体移植排斥和植入生物材料的治疗。由于 DCs 在免疫调节生物材料中的重要性不断增加，本综述总结了 DCs 对生物材料的反应，如黏附、迁移和成熟。我们还回顾了一些关键分子的例子及其在 DC 免疫工程中的应用。这些评估将为设计先进的生物材料和纳米材料以调节免疫系统铺平道路，适用于组织工程、移植和药物输送技术。
