J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611 USA.
Department of Biomedical Engineering, University of California, Davis, CA 95616, USA.
Semin Immunol. 2017 Feb;29:33-40. doi: 10.1016/j.smim.2017.04.002. Epub 2017 May 7.
The role of dendritic cells (DCs) and their targeted manipulation in the body's response to implanted materials is an important and developing area of investigation, and a large component of the emerging field of biomaterials-based immune engineering. The key position of DCs in the immune system, serving to bridge innate and adaptive immunity, is facilitated by rich diversity in type and function and places DCs as a critical mediator to biomaterials of both synthetic and natural origins. This review presents current views regarding DC biology and summarizes recent findings in DC responses to implanted biomaterials. Based on these findings, there is promise that the directed programming of application-specific DC responses to biomaterials can become a reality, enabling and enhancing applications almost as diverse as the larger field of biomaterials itself.
树突状细胞(DCs)在体内对植入材料的反应中的作用及其靶向调控是一个重要且不断发展的研究领域,也是基于生物材料的免疫工程这一新兴领域的重要组成部分。DCs 在免疫系统中的关键位置,充当固有免疫和适应性免疫之间的桥梁,这得益于其丰富的多样性和功能,使 DCs 成为合成和天然来源的生物材料的关键介质。本文综述了目前关于 DC 生物学的观点,并总结了 DC 对植入生物材料的反应的最新发现。基于这些发现,有望实现对生物材料的特定应用的 DC 反应的定向编程,从而使生物材料的应用几乎像更大的生物材料领域一样多样化。