J Clin Invest. 2021 Jan 19;131(2). doi: 10.1172/JCI144994.
The increase in food allergy prevalence in recent years suggests that environmental factors, such as diet and intestinal microbiota, play contributory roles. In this issue of the JCI, Bao et al. compared twins that differed with respect to food allergies. The researchers analyzed sequences from microbe ribosomal RNA and profiled microbe metabolites, identifying health-associated microbes at the species level. In addition to revealing microbes from the Clostridia class enriched in healthy twins, the authors identified two commensal species (Phascolarctobacterium faecium and Ruminococcus bromii) related to the healthy fecal metabolome. This study advances the goal for next-generation probiotic therapies that effectively treat or prevent food allergy.
近年来，食物过敏的发病率不断上升，这表明环境因素，如饮食和肠道微生物群，可能起到了一定的作用。在本期《临床检查杂志》中，Bao 等人比较了在食物过敏方面存在差异的双胞胎。研究人员分析了微生物核糖体 RNA 的序列，并对微生物代谢物进行了分析，在物种水平上确定了与健康相关的微生物。除了发现健康双胞胎体内富集的梭菌属微生物外，作者还鉴定出两种与健康粪便代谢组相关的共生种（粪硬脂球菌和布劳特氏菌）。这项研究推进了下一代益生菌疗法的目标，即有效治疗或预防食物过敏。
