Center for Excellence in Cornea and Ocular Surface Disorders, Excel Eye Care, Ahmedabad, Gujarat, India.
Centre for Ocular Regeneration; The Cornea Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India.
Indian J Ophthalmol. 2021 Feb;69(2):433-435. doi: 10.4103/ijo.IJO_1952_20.
A 23-year-old man presented with congestion, peripheral corneal vascularization, an elevated ridge-like epithelial line and cellular infiltration around limbal transplants, 15 months after undergoing living-related simple limbal epithelial transplantation (SLET) for total limbal stem cell deficiency. A diagnosis of acute allograft rejection was made and he was treated with intravenous methylprednisolone, topical and oral prednisolone as well as systemic cyclosporine and azathioprine, leading to reversal of the signs. Similar findings were noted during a later rejection episode. An epithelial rejection line and cellular infiltration of limbal transplants are easily identifiable clinical signs of allograft rejection post SLET.
一位 23 岁男性在因全角膜缘干细胞缺乏症接受活体相关单纯角膜缘上皮移植（SLET）后 15 个月，出现充血、周边角膜血管化、高起的脊状上皮线和移植物边缘细胞浸润。诊断为急性同种异体移植物排斥反应，给予静脉甲基泼尼松龙、局部和口服泼尼松龙以及全身环孢素和硫唑嘌呤治疗，导致排斥反应逆转。在后来的排斥反应发作中也观察到类似的发现。SLET 后，同种异体移植排斥的上皮排斥线和移植物边缘细胞浸润是容易识别的临床排斥征象。
