Holmberg K, Bake B, Pipkorn U
Department of Otorhinolaryngology, Lundby Hospital, Gothenburg University, Sweden.
J Allergy Clin Immunol. 1988 Mar;81(3):541-7.
The nasal mucosal blood flow in patients with allergic rhinitis was determined at nasal allergen challenges with the 133Xenon washout method. Determinations were made in 12 subjects before and 15 minutes after challenge with diluent and increasing doses of allergen. The time course was followed in eight subjects by means of repeated measurements during 1 hour after a single allergen dose. Finally, the blood flow was measured after unilateral allergen challenge in the contralateral nasal cavity. A dose-dependent decrease in blood flow was found after nasal challenge with increasing doses of allergens, whereas challenge with diluent alone did not induce any changes. The highest allergen dose, which also induced pronounced nasal symptoms, resulted in a decrease in blood flow of 25% (p less than 0.001). The time-course study demonstrated a maximum decrease in blood flow 10 to 20 minutes after challenge and then a gradual return to baseline. Unilateral allergen challenge resulted in a decrease in blood flow in the contralateral, unchallenged nasal cavity, suggesting that part of the allergen-induced changes in blood flow were reflex mediated.
采用¹³³氙洗脱法在鼻腔过敏原激发试验中测定变应性鼻炎患者的鼻黏膜血流量。对12名受试者在使用稀释剂和递增剂量过敏原激发前及激发后15分钟进行测定。通过在单次给予过敏原剂量后1小时内对8名受试者进行重复测量来跟踪时间进程。最后，在对侧鼻腔进行单侧过敏原激发后测量血流量。在使用递增剂量过敏原进行鼻腔激发后发现血流量呈剂量依赖性下降，而仅使用稀释剂激发未引起任何变化。导致明显鼻部症状的最高过敏原剂量使血流量下降了25%（p<0.001）。时间进程研究表明，激发后10至20分钟血流量下降最大，然后逐渐恢复至基线水平。单侧过敏原激发导致对侧未激发鼻腔的血流量下降，这表明过敏原诱导的血流量变化部分是由反射介导的。
