Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P. R. China.
National Engineering Research Center for Biomaterials, Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610064, P. R. China.
ACS Biomater Sci Eng. 2020 Feb 10;6(2):842-851. doi: 10.1021/acsbiomaterials.9b01148. Epub 2020 Jan 7.
Polyetheretherketone (PEEK) is becoming an attractive surgical implant material in the biomedical field. However, its hydrophobicity and biological inertia have seriously hindered its development in the field of biomaterials and application in clinic. In this work, a mixed modification approach of the surface structure and chemical state was proposed to improve hydrophilicity and bioactivity of PEEK and meanwhile endowed it with antimicrobial properties. First, the effect of mixed acids of nitric acid and concentrated sulfuric acid with different volume ratios on the surface morphology of PEEK was quantitatively investigated, so as to obtain an optimal mixed acid of nitric acid and concentrated sulfuric acid with a volume ratio that could create a multilevel porous structure. Based on this, chemical grafting of ethylenediamine was conducted to achieve amination on the surface of the PEEK. The results showed that such double modification of the surface structure and chemical state could endow PEEK not only with antimicrobial activity but also with good hydrophilicity, cell compatibility, and bioactivity, which were beneficial to improve the bone integration ability of PEEK greatly.
聚醚醚酮（PEEK）作为一种具有吸引力的医用植入材料，在生物医学领域得到了广泛的关注。然而，其疏水性和生物惰性严重限制了它在生物材料领域的发展和临床应用。在本工作中，提出了一种表面结构和化学状态的混合修饰方法，以提高 PEEK 的亲水性和生物活性，同时赋予其抗菌性能。首先，定量研究了不同体积比的混合酸（硝酸和浓硫酸）对 PEEK 表面形貌的影响，以获得能够创造多级多孔结构的最佳混合酸体积比。在此基础上，进行了乙二胺的化学接枝，实现了 PEEK 表面的氨基化。结果表明，这种表面结构和化学状态的双重修饰不仅赋予了 PEEK 抗菌活性，而且赋予了良好的亲水性、细胞相容性和生物活性，这有利于极大地提高 PEEK 的骨整合能力。
