Sarkar Debina, Diermeier Sarah D
Department of Biochemistry, University of Otago, Dunedin 9016, New Zealand.
Noncoding RNA. 2021 Jan 5;7(1):2. doi: 10.3390/ncrna7010002.
Circular RNAs (circRNAs) are a class of non-coding RNAs that form a covalently closed loop. A number of functions and mechanisms of action for circRNAs have been reported, including as miRNA sponge, exerting transcriptional and translational regulation, interacting with proteins, and coding for peptides. CircRNA dysregulation has also been implicated in many cancers, such as breast cancer. Their relatively high stability and presence in bodily fluids makes cancer-associated circRNAs promising candidates as a new biomarker. In this review, we summarize the research undertaken on circRNAs associated with breast cancer, discuss circRNAs as biomarkers, and present circRNA-based therapeutic approaches.
环状RNA（circRNA）是一类形成共价闭合环的非编码RNA。已报道了circRNA的多种功能和作用机制，包括作为微小RNA（miRNA）海绵、发挥转录和翻译调控作用、与蛋白质相互作用以及编码肽段。circRNA失调也与许多癌症有关，如乳腺癌。它们相对较高的稳定性以及在体液中的存在，使得癌症相关的circRNA有望成为一种新的生物标志物。在本综述中，我们总结了与乳腺癌相关的circRNA的研究，讨论了circRNA作为生物标志物的情况，并介绍了基于circRNA的治疗方法。
