Department of Medical Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Fudan University Shanghai Cancer Center, Shanghai Key Laboratory of Medical Epigenetics, Institute of Biomedical Sciences, Fudan University, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Cancer Lett. 2020 Oct 1;489:111-120. doi: 10.1016/j.canlet.2020.06.006. Epub 2020 Jun 16.
Extracellular vesicles (EVs) have been recognized as vital mediators of intercellular communication that allow horizontal information exchange among tumor cells as well as reciprocal cross-talk between tumor and stromal cells. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are selectively packaged into EVs then transferred to proximal and distal recipient cells, inducing profound phenotypic changes. Recently, there has been substantial progress in understanding the essential roles of EV-associated lncRNAs and circRNAs in cancer initiation and progression. The distinctive properties of these ncRNAs carried by EVs, including their tissue-specific expression, relative stability, targeted delivery and widespread presence in various biofluids, has also prompted the exploration of their potential in liquid biopsy and therapeutic usage. Herein, we summarized the biology, characteristics and functions of EV-associated lncRNAs and circRNAs, highlighting their vital roles in hallmarks of cancer and their prospective applications in cancer management. The challenges unresolved in this field were additionally pointed out to guide future studies.
细胞外囊泡 (EVs) 已被认为是细胞间通讯的重要介质，允许肿瘤细胞之间进行水平信息交换，以及肿瘤细胞与基质细胞之间的相互交流。长非编码 RNA (lncRNAs) 和环状 RNA (circRNAs) 被选择性地包装到 EVs 中，然后转移到邻近和远端的受体细胞，诱导深刻的表型变化。最近，人们在理解 EV 相关 lncRNAs 和 circRNAs 在癌症发生和进展中的重要作用方面取得了实质性进展。这些由 EV 携带的 ncRNAs 的独特特性，包括其组织特异性表达、相对稳定性、靶向传递和广泛存在于各种生物体液中，也促使人们探索它们在液体活检和治疗应用中的潜力。本文总结了 EV 相关 lncRNAs 和 circRNAs 的生物学、特征和功能，强调了它们在癌症特征中的重要作用及其在癌症管理中的潜在应用。此外，还指出了该领域尚未解决的挑战，以指导未来的研究。
