Department of Neonatology, Hôpital La Conception, Hôpitaux Universitaires de Marseille, 13005 Marseille, France.
Research Unit EA 3279 and Department of Public Health, Aix-Marseille University, 13005 Marseille, France.
Nutrients. 2021 Jan 14;13(1):227. doi: 10.3390/nu13010227.
The purpose of this study was to determine the influence of first-week nutrition intake on neonatal growth in moderate preterm (MP) infants. Data on neonatal morbidity and nutrition intake on day of life 7 (DoL7) were prospectively collected from 735 MP infants (32-34 weeks gestational age (GA)). Multivariable regression was used to assess the factors associated with extrauterine growth restriction (EUGR) defined as a decrease of more than 1 standard deviation () in the weight -score during hospitalization. Mean () gestational age and birth weight were 33.2 (0.8) weeks and 2005 (369) g. The mean change in the weight -score during hospitalization was -0.64 . A total of 138 infants (18.8%) had EUGR. Compared to adequate growth infants, EUGR infants received 15% and 35% lower total energy and protein intake respectively ( < 0.001) at DoL7. At DoL7, each increase of 10 kcal/kg/d and 1 g/kg/d of protein was associated with reduced odds of EUGR with an odds ratio of 0.73 (95% CI, 0.66-0.82; < 0.001) and 0.54 (0.44-0.67; < 0.001), respectively. Insufficient energy and protein intakes on DoL7 negatively affected neonatal growth of MP infants. Nutritional support should be optimized from birth onwards to improve neonatal weight growth.
本研究旨在确定早产儿（MP）第一周营养摄入对新生儿生长的影响。从 735 名 MP 婴儿（32-34 周胎龄（GA））中前瞻性收集了关于新生儿发病率和第 7 天（DoL7）营养摄入的数据。多变量回归用于评估与宫外生长受限（EUGR）相关的因素，EUGR 定义为住院期间体重评分下降超过 1 个标准差（）。平均（）胎龄和出生体重分别为 33.2（0.8）周和 2005（369）g。住院期间体重评分的平均变化为-0.64。共有 138 名婴儿（18.8%）发生 EUGR。与生长良好的婴儿相比，EUGR 婴儿在 DoL7 时的总能量和蛋白质摄入量分别低 15%和 35%（<0.001）。在 DoL7 时，每天增加 10 千卡/公斤和 1 克/公斤的蛋白质与 EUGR 发生的几率降低相关，比值比（OR）分别为 0.73（95%可信区间，0.66-0.82；<0.001）和 0.54（0.44-0.67；<0.001）。DoL7 时能量和蛋白质摄入不足会对 MP 婴儿的新生儿生长产生负面影响。应从出生开始优化营养支持，以改善新生儿体重增长。
