Brushart T M
Department of Orthopaedics, Johns Hopkins Hosptial, Baltimore, Maryland 21218.
J Neurosci. 1988 Mar;8(3):1026-31. doi: 10.1523/JNEUROSCI.08-03-01026.1988.
Regeneration of axons into inappropriate distal nerve branches may adversely affect functional recovery after peripheral nerve suture. The degree to which motor axons reinnervate sensory nerves, and vice versa, has not been determined. In these experiments, HRP is used to quantify the sensory and motor neurons that reinnervate sensory and motor branches of the rat femoral nerve after proximal severance and repair. Motoneurons preferentially reinnervate the motor branch in juveniles and adults, even if the repair is intentionally misaligned or a gap is imposed between proximal and distal stumps. A specific interaction thus occurs between regenerating motor axons and the Schwann cell tubes that lead to the motor branch. This interaction is independent of mechanical axon alignment.
轴突再生进入不适当的远端神经分支可能会对周围神经缝合后的功能恢复产生不利影响。运动轴突重新支配感觉神经以及感觉轴突重新支配运动神经的程度尚未确定。在这些实验中，使用辣根过氧化物酶（HRP）来量化大鼠股神经近端切断并修复后重新支配感觉和运动分支的感觉神经元和运动神经元。即使修复故意错位或在近端和远端残端之间设置间隙，运动神经元在幼年和成年大鼠中仍优先重新支配运动分支。因此，再生的运动轴突与通向运动分支的雪旺细胞管之间会发生特定的相互作用。这种相互作用与轴突的机械排列无关。
