Maki Y, Yoshizu T, Tajima T, Narisawa H
Niigata Hand Surgery Foundation, Japan.
J Reconstr Microsurg. 1996 Nov;12(8):547-51. doi: 10.1055/s-2007-1006628.
Functional results of peripheral nerve repair have been hampered by misdirection of regenerating axons. The purpose of this study was to determine in a rat femoral nerve model whether regenerating motor and sensory axons from a proximal nerve stump select the appropriate distal motor or sensory branch. In two experiments, the proximal stump of the motor or sensory branches was sutured to the distal motor sensory stumps, so that the three branches were parallel and the three transected ends faced in the same direction. More regenerated axons from both the proximal motor and sensory stumps entered the distal sensory stump. The number of misdirected axons did not decrease over time. The selective regeneration of motor axons toward the distal motor stump could not be validated. In this study, neurotropism appeared to play a measurable role in sensory axon regeneration, but not in motor axon regeneration. Pruning of the misdirected axons was not demonstrated.
周围神经修复的功能结果因再生轴突的误定向而受到阻碍。本研究的目的是在大鼠股神经模型中确定，来自近端神经残端的再生运动轴突和感觉轴突是否会选择合适的远端运动或感觉分支。在两个实验中，将运动或感觉分支的近端残端缝合到远端运动或感觉残端，使三个分支平行且三个横断端朝向同一方向。来自近端运动和感觉残端的更多再生轴突进入了远端感觉残端。误定向轴突的数量并未随时间减少。运动轴突向远端运动残端的选择性再生未得到证实。在本研究中，神经趋向性似乎在感觉轴突再生中发挥了可测量的作用，但在运动轴突再生中并非如此。未证实对误定向轴突的修剪。
