Byrne Niall M, Tambe Prajakta, Coulter Jonathan A
School of Pharmacy, Queens University Belfast, Lisburn Road, Belfast BT9 7BL, UK.
J Pers Med. 2021 Jan 16;11(1):53. doi: 10.3390/jpm11010053.
Radiotherapy (RT) is a primary treatment modality for a number of cancers, offering potentially curative outcomes. Despite its success, tumour can become resistant to RT, leading to disease recurrence. Components of the tumour microenvironment (TME) likely play an integral role in managing RT success or failure including infiltrating immune , the tumour vasculature and stroma. Furthermore, genomic profiling of the TME could identify predictive biomarkers or gene signatures indicative of RT response. In this review, we will discuss proposed mechanisms of radioresistance within the TME, biomarkers that may predict RT outcomes, and future perspectives on radiation treatment in the era of personalised medicine.
放射疗法（RT）是多种癌症的主要治疗方式，可能带来治愈效果。尽管取得了成功，但肿瘤可能会对放疗产生抗性，导致疾病复发。肿瘤微环境（TME）的组成部分可能在放疗的成败中起着不可或缺的作用，包括浸润性免疫细胞、肿瘤脉管系统和基质。此外，TME的基因组分析可以识别预测放疗反应的生物标志物或基因特征。在这篇综述中，我们将讨论TME内放射抗性的潜在机制、可能预测放疗结果的生物标志物以及个性化医疗时代放射治疗的未来前景。
