Wen Pengbo, Gao Yang, Chen Bin, Qi Xiaojing, Hu Guanshuo, Xu An, Xia Junfeng, Wu Lijun, Lu Huayi, Zhao Guoping
Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences; Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology, Hefei 230031, China.
University of Science and Technology of China, Hefei 230026, China.
Cancers (Basel). 2020 Apr 13;12(4):957. doi: 10.3390/cancers12040957.
Response to radiotherapy (RT) in cancers varies widely among patients. Therefore, it is very important to predict who will benefit from RT before clinical treatment. Consideration of the immune tumor microenvironment (TME) could provide novel insight into tumor treatment options. In this study, we investigated the link between immune infiltration status and clinical RT outcome in order to identify certain leukocyte subsets that could potentially influence the clinical RT benefit across cancers. By integrally analyzing the TCGA data across seven cancers, we identified complex associations between immune infiltration and patients RT outcomes. Besides, immune cells showed large differences in their populations in various cancers, and the most abundant cells were resting memory CD4 T cells. Additionally, the proportion of activated CD4 memory T cells and activated mast cells, albeit at low number, were closely related to RT overall survival in multiple cancers. Furthermore, a prognostic model for RT outcomes was established with good performance based on the immune infiltration status. Summarized, immune infiltration was found to be of significant clinical relevance to RT outcomes. These findings may help to shed light on the impact of tumor-associated immune cell infiltration on cancer RT outcomes, and identify biomarkers and therapeutic targets.
癌症患者对放疗（RT）的反应差异很大。因此，在临床治疗前预测谁将从放疗中获益非常重要。考虑免疫肿瘤微环境（TME）可为肿瘤治疗方案提供新的见解。在本研究中，我们调查了免疫浸润状态与临床放疗结果之间的联系，以确定某些可能影响各种癌症临床放疗获益的白细胞亚群。通过综合分析来自七种癌症的TCGA数据，我们确定了免疫浸润与患者放疗结果之间的复杂关联。此外，免疫细胞在各种癌症中的数量存在很大差异，其中最丰富的细胞是静息记忆CD4 T细胞。此外，活化的CD4记忆T细胞和活化的肥大细胞比例虽然数量较少，但与多种癌症的放疗总生存期密切相关。此外，基于免疫浸润状态建立了一个性能良好的放疗结果预后模型。总之，发现免疫浸润与放疗结果具有显著的临床相关性。这些发现可能有助于阐明肿瘤相关免疫细胞浸润对癌症放疗结果的影响，并识别生物标志物和治疗靶点。
