Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK.
Int J Mol Sci. 2021 Jan 16;22(2):874. doi: 10.3390/ijms22020874.
Plant cyclic nucleotide-gated channels (CNGCs) are tetrameric cation channels which may be activated by the cyclic nucleotides (cNMPs) adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5'-cyclic monophosphate (cGMP). The genome of encodes 20 CNGC subunits associated with aspects of development, stress response and immunity. Recently, it has been demonstrated that CNGC subunits form heterotetrameric complexes which behave differently from the homotetramers produced by their constituent subunits. These findings have widespread implications for future signalling research and may help explain how specificity can be achieved by CNGCs that are known to act in disparate pathways. Regulation of complex formation may involve cyclic nucleotide-gated channel-like proteins.
植物环核苷酸门控通道（CNGCs）是由环核苷酸（cNMPs）环腺苷酸（cAMP）和环鸟苷酸（cGMP）激活的四聚体阳离子通道。编码 20 个 CNGC 亚基，与发育、应激反应和免疫有关。最近，已经证明 CNGC 亚基形成异四聚体复合物，其行为与由其组成亚基产生的同四聚体不同。这些发现对未来的信号转导研究具有广泛的意义，并可能有助于解释为什么众所周知在不同途径中起作用的 CNGCs 可以实现特异性。复合物形成的调节可能涉及环核苷酸门控通道样蛋白。
