Institute of Biosciences and Bioresources, National Research Council, Via G. Amendola 165/A, 70126 Bari, Italy.
Department of Biology, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy.
Int J Mol Sci. 2020 Jul 9;21(14):4862. doi: 10.3390/ijms21144862.
The cyclic nucleotide cAMP (3',5'-cyclic adenosine monophosphate) is nowadays recognised as an important signalling molecule in plants, involved in many molecular processes, including sensing and response to biotic and abiotic environmental stresses. The validation of a functional cAMP-dependent signalling system in higher plants has spurred a great scientific interest on the polyhedral role of cAMP, as it actively participates in plant adaptation to external stimuli, in addition to the regulation of physiological processes. The complex architecture of cAMP-dependent pathways is far from being fully understood, because the actors of these pathways and their downstream target proteins remain largely unidentified. Recently, a genetic strategy was effectively used to lower cAMP cytosolic levels and hence shed light on the consequences of cAMP deficiency in plant cells. This review aims to provide an integrated overview of the current state of knowledge on cAMP's role in plant growth and response to environmental stress. Current knowledge of the molecular components and the mechanisms of cAMP signalling events is summarised.
环核苷酸 cAMP（3'，5'-环腺苷酸单磷酸）如今被认为是植物中一种重要的信号分子，参与许多分子过程，包括感应和响应生物和非生物环境胁迫。在高等植物中验证功能性 cAMP 依赖的信号系统激发了人们对 cAMP 多面角色的极大科学兴趣，因为它除了调节生理过程外，还积极参与植物对外界刺激的适应。cAMP 依赖途径的复杂结构远未被完全理解，因为这些途径的参与者及其下游靶蛋白仍然在很大程度上未被识别。最近，一种遗传策略被有效地用于降低 cAMP 胞质溶胶水平，从而揭示了 cAMP 缺乏对植物细胞的影响。本综述旨在提供对 cAMP 在植物生长和响应环境胁迫中的作用的当前知识的综合概述。总结了 cAMP 信号事件的分子成分和机制的现有知识。
