Cariati Ida, Scimeca Manuel, Tancredi Virginia, D'Amico Agata Grazia, Pallone Gabriele, Palmieri Mattia, Frank Claudio, D'Arcangelo Giovanna
Medical-Surgical Biotechnologies and Translational Medicine, Department of Clinical Sciences and Translational Medicine, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.
Department of Biomedicine and Prevention, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.
J Funct Morphol Kinesiol. 2020 Jul 18;5(3):53. doi: 10.3390/jfmk5030053.
The positive effects of physical activity on cognitive functions are widely known. Aerobic training is known to promote the expression of neurotrophins, thus inducing an increase in the development and survival of neurons, as well as enhancing synaptic plasticity. Based on this evidence, in the present study, we analyze the effects of two different types of aerobic training, progressive continuous (PC) and varying continuous (VC), on synaptic and muscular plasticity in heterozygous mice carrying the genetic mutation for Niemann-Pick type C disease. We also analyze the effects on synaptic plasticity by extracellular recordings in vitro in mouse hippocampal slices, while the morphological structure of muscle tissue was studied by transmission electron microscopy. Our results show a modulation of synaptic plasticity that varies according to the type of training protocol used, and only the VC protocol administered twice a week, has a significantly positive effect on long-term potentiation. On the contrary, ultrastructural analysis of muscle tissue shows an improvement in cellular conditions in all trained mice. These results confirm the beneficial effects of exercise on quality of life, supporting the hypothesis that physical activity could represent an alternative therapeutic strategy for patients with Niemann-Pick type C disease.
体育活动对认知功能的积极影响广为人知。有氧训练已知可促进神经营养因子的表达，从而促使神经元的发育和存活增加，并增强突触可塑性。基于这一证据，在本研究中，我们分析了两种不同类型的有氧训练，即渐进持续（PC）训练和可变持续（VC）训练，对携带尼曼-匹克C型病基因突变的杂合小鼠的突触和肌肉可塑性的影响。我们还通过体外对小鼠海马切片进行细胞外记录来分析对突触可塑性的影响，同时通过透射电子显微镜研究肌肉组织的形态结构。我们的结果表明，突触可塑性的调节因所使用的训练方案类型而异，并且只有每周进行两次的VC方案对长时程增强有显著的积极影响。相反，肌肉组织的超微结构分析显示，所有接受训练的小鼠的细胞状况都有所改善。这些结果证实了运动对生活质量的有益影响，支持了体育活动可能是尼曼-匹克C型病患者的一种替代治疗策略的假设。
