Departamento de Neurociencia Cognitiva, División Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico, Mexico.
Channels (Austin). 2024 Dec;18(1):2313323. doi: 10.1080/19336950.2024.2313323. Epub 2024 Feb 14.
The members of the superfamily of Transient Receptor Potential (TRP) ion channels are physiologically important molecules that have been studied for many years and are still being intensively researched. Among the vanilloid TRP subfamily, the TRPV4 ion channel is an interesting protein due to its involvement in several essential physiological processes and in the development of various diseases. As in other proteins, changes in its function that lead to the development of pathological states, have been closely associated with modification of its regulation by different molecules, but also by the appearance of mutations which affect the structure and gating of the channel. In the last few years, some structures for the TRPV4 channel have been solved. Due to the importance of this protein in physiology, here we discuss the recent progress in determining the structure of the TRPV4 channel, which has been achieved in three species of animals (, , and ), highlighting conserved features as well as key differences among them and emphasizing the binding sites for some ligands that play crucial roles in its regulation.
瞬时受体电位 (TRP) 离子通道超家族的成员是生理上重要的分子，多年来一直受到研究，并且仍在深入研究。在香草素 TRP 亚家族中，TRPV4 离子通道是一种有趣的蛋白质，因为它参与了几种重要的生理过程和多种疾病的发展。与其他蛋白质一样，导致病态发生的功能变化与其调节的变化密切相关，这种调节变化既可以由不同分子的修饰引起，也可以由影响通道门控的突变引起。在过去的几年中，已经解决了一些 TRPV4 通道的结构。由于该蛋白质在生理学中的重要性，我们在这里讨论了最近在确定 TRPV4 通道结构方面的进展，这些进展在三种动物（大鼠、猪和斑马鱼）中实现，突出了它们之间的保守特征和关键差异，并强调了一些配体的结合位点，这些配体在其调节中起着关键作用。
