Detrimental Impact of Trans Fats on Human Health: Stearic Acid-Rich Fats as Possible Substitutes.

Strong evidence demonstrated the negative effect of trans fatty acid (TFA) intake on cardiovascular diseases (CVD), diabetes, systemic inflammation, and hemostasis. As a consequence, different regulatory actions have been developed around the world, aiming to reduce human consumption of TFA. Replacement for TFA functionality requires incorporation of plastic and stable saturated fats; the present options are palm or fully hydrogenated oils. Palm oil has been described as responsible for negative biological effects on serum cholesterol levels and CVD risk. Different epidemiological and clinical studies recommend reduction of saturated fatty acid (SFA) intake, mainly myristic and palmitic acids. Experimental evidence strongly suggests that stearic acid is a wholesome substitute for TFAs and other SFAs in food manufacturing. In this article, biological effects of stearic acid on human health are reviewed in comparison to TFAs, SFAs, and unsaturated fatty acids. Current revised understanding on dietary intake, digestion, and absorption is also covered.