Lin Zizhen, Qin Xianhui, Yang Yaya, Huang Yan, Wang Jieyu, Kong Yaozhong, Li Yumin, Yang Shenglin, Lu Yongxin, Zhao Yanhong, Li Youbao, Wan Qijun, Wang Qi, Huang Sheng, Liu Yan, Liu Aiqun, Liu Fanna, Hou FanFan, Liang Min
National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Renal Division, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, Guangzhou, People's Republic of China.
The First People's Hospital of Foshan, Foshan, People's Republic of China.
Br J Nutr. 2021 Nov 28;126(10):1510-1518. doi: 10.1017/S0007114521000210. Epub 2021 Jan 20.
High fibre intake is associated with reduced mortality risk in both general and chronic kidney disease populations. However, in dialysis patients, such data are limited. Therefore, the association between dietary fibre intake (DFI) and the risk of all-cause and CVD mortality was examined in this study. A total of 1044 maintenance haemodialysis (MHD) patients from eight outpatient dialysis centres in China were included in this study. Data on DFI were collected using 24-h dietary recalls for 3 d in a week and were normalised to actual dry weight. The study outcomes included all-cause and CVD mortality. Over a median of 46 months of follow-up, 354 deaths were recorded, of which 210 (59 %) were due to CVD. On assessing DFI as tertiles, the CVD mortality risk was significantly lower in patients in tertiles 2-3 (≥0·13 g/kg per d; hazard ratio (HR) 0·71; 95 % CI 0·51, 0·97) compared with those in tertile 1 (<0·13 g/kg per d). A similar but non-significant trend was found for the association between DFI (tertiles 2-3 v. tertile 1; HR 0·83; 95 % CI 0·64, 1·07) and all-cause mortality. In summary, higher DFI was associated with lower CVD mortality risk among Chinese MHD patients. This study emphasises the significance of DFI in MHD patients and provides information that is critical for the improvement of dietary guidelines for dialysis patients.
高纤维摄入量与普通人群和慢性肾病患者的死亡风险降低相关。然而，在透析患者中，此类数据有限。因此，本研究探讨了膳食纤维摄入量（DFI）与全因死亡率和心血管疾病（CVD）死亡率风险之间的关联。本研究纳入了来自中国八个门诊透析中心的1044例维持性血液透析（MHD）患者。通过连续一周3天的24小时饮食回顾收集DFI数据，并将其换算为实际干重。研究结局包括全因死亡率和CVD死亡率。在中位随访46个月期间，记录了354例死亡病例，其中210例（59%）死于CVD。将DFI分为三分位数进行评估时，与第一三分位数（<0·13 g/kg per d）的患者相比，第二至第三三分位数（≥0·13 g/kg per d）的患者CVD死亡风险显著降低（风险比（HR）0·71；95%置信区间0·51，0·97）。在DFI与全因死亡率之间的关联方面也发现了类似但不显著的趋势（第二至第三三分位数与第一三分位数相比；HR 0·83；95%置信区间0·64，1·07）。总之，较高的DFI与中国MHD患者较低的CVD死亡风险相关。本研究强调了DFI在MHD患者中的重要性，并为改进透析患者饮食指南提供了关键信息。
