红色毛癣菌对他唑巴坦的耐药性及耐药演变。
Resistance and Evolution of Resistance to Tavaborole in Trichophyton rubrum.
机构信息
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
出版信息
Antimicrob Agents Chemother. 2021 Mar 18;65(4). doi: 10.1128/AAC.02324-20.
Abstract
Tavaborole is currently used in the topical treatment of onychomycosis. In this study, we analyzed the emergence/evolution of resistance against tavaborole in When strains were propagated on media containing the MIC of tavaborole, spontaneous resistant mutants were isolated at a frequency of 10 The frequency was almost 100-fold higher following fungal growth in the presence of a subinhibitory tavaborole concentration (0.5-fold the MIC) for 10 transfers. All collected mutants showed similar 4- to 8-fold increases in the drug MIC. No cross-resistance to other antifungals was evident.
摘要
他伐硼罗目前被用于治疗甲真菌病。在这项研究中，我们分析了他伐硼罗耐药性的出现/进化。当在含有他伐硼罗 MIC 的培养基中传代培养时，自发耐药突变体以 10 的频率分离出来。当真菌在亚抑菌浓度（MIC 的 0.5 倍）的他伐硼罗存在下生长 10 代时，频率几乎增加了 100 倍。所有收集到的突变体对药物 MIC 的增加相似，为 4 到 8 倍。没有对其他抗真菌药物的交叉耐药性。
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