硼替佐米具有强大的抗肿瘤和抗血管生成活性。
Boromycin Has Potent Anti- and Anti- Activity.
机构信息
Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.
College of Veterinary Science and Medicine, Central Luzon State University, Science City of Muñoz, Nueva Ecija, Philippines.
出版信息
Antimicrob Agents Chemother. 2021 Mar 18;65(4). doi: 10.1128/AAC.01278-20.
and , members of the phylum Apicomplexa, are significant pathogens of both humans and animals worldwide for which new and effective therapeutics are needed. Here, we describe the activity of the antibiotic boromycin against and Boromycin potently inhibited intracellular proliferation of both and at half-maximal effective concentrations (EC) of 2.27 nM and 4.99 nM, respectively. Treatment of extracellular tachyzoites with 25 nM boromycin for 30 min suppressed 84% of parasite growth, but tachyzoite invasion into host cells was not affected by boromycin. Immunofluorescence of boromycin-treated showed loss of morphologically intact parasites with randomly distributed surface antigens inside the parasitophorous vacuoles. Boromycin exhibited a high selectivity for the parasites over their host cells. These results suggest that boromycin is a promising new drug candidate for treating toxoplasmosis and cryptosporidiosis.
并且，门顶复体纲的成员，是全球范围内人类和动物的重要病原体，需要新的和有效的治疗方法。在这里，我们描述了抗生素硼霉素对和的活性。硼霉素对和的半数有效浓度（EC）分别为 2.27 nM 和 4.99 nM，强烈抑制了这两种寄生虫的细胞内增殖。用 25 nM 的硼霉素处理 30 分钟，可抑制 84%的寄生虫生长，但硼霉素不会影响速殖子侵入宿主细胞。硼霉素处理后的免疫荧光显示，形态完整的寄生虫丢失，寄生空泡内的表面抗原随机分布。硼霉素对寄生虫表现出很高的选择性，而对其宿主细胞则没有。这些结果表明，硼霉素是一种很有前途的治疗弓形虫病和隐孢子虫病的新药候选物。
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